Molecular genetic studies of major histocompatibility complex genes in children with Juvenile dermatomyositis: Increased risk associated with HLA-DQA1*0501

Ann M. Reed, Lauren Pachman, Carole Ober

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

Juvenile dermatomyositis (JDMS) is an inflammatory disease associated with HLA-DR3. We therefore undertook molecular genetic studies of HLA region genes to determine whether HLA-DR3 itself confers susceptibility to JDMS or whether susceptibility is conferred by alleles in linkage disequilibrium with HLA-DR3. Our results indicate that JDMS is associated with the HLA-DQA1 allele DQA1*0501 on non-DR3 haplotypes in Caucasian JDMS. Furthermore, the reported of association between the C4A gene deletion and JDMS is likely due to linkage disequilibrium with HLA-DR3. Human Immunology 32, 235-240 (1991).

Original languageEnglish (US)
Pages (from-to)235-240
Number of pages6
JournalHuman Immunology
Volume32
Issue number4
DOIs
StatePublished - Dec 1991

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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