Molecular genetic studies of major histocompatibility complex genes in children with Juvenile dermatomyositis

Increased risk associated with HLA-DQA1*0501

Ann M. Reed, Lauren Pachman, Carole Ober

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Juvenile dermatomyositis (JDMS) is an inflammatory disease associated with HLA-DR3. We therefore undertook molecular genetic studies of HLA region genes to determine whether HLA-DR3 itself confers susceptibility to JDMS or whether susceptibility is conferred by alleles in linkage disequilibrium with HLA-DR3. Our results indicate that JDMS is associated with the HLA-DQA1 allele DQA1*0501 on non-DR3 haplotypes in Caucasian JDMS. Furthermore, the reported of association between the C4A gene deletion and JDMS is likely due to linkage disequilibrium with HLA-DR3. Human Immunology 32, 235-240 (1991).

Original languageEnglish (US)
Pages (from-to)235-240
Number of pages6
JournalHuman Immunology
Volume32
Issue number4
DOIs
StatePublished - 1991
Externally publishedYes

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HLA-DR3 Antigen
Major Histocompatibility Complex
Molecular Biology
Genes
Linkage Disequilibrium
Alleles
Gene Deletion
Allergy and Immunology
Haplotypes
Juvenile dermatomyositis
HLA-DQA1 antigen

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Molecular genetic studies of major histocompatibility complex genes in children with Juvenile dermatomyositis : Increased risk associated with HLA-DQA1*0501. / Reed, Ann M.; Pachman, Lauren; Ober, Carole.

In: Human Immunology, Vol. 32, No. 4, 1991, p. 235-240.

Research output: Contribution to journalArticle

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