Molecular genetic approaches for the diagnosis of clonality in lymphoid neoplasms

C. L. Willman, B. B. Griffith, M. Whittaker

Research output: Contribution to journalReview articlepeer-review

Abstract

The isolation of human DNA sequences that encode immunoglobulin genes, T cell receptor genes, and proto-oncogenes involved in the pathogenesis of lymphoid neoplasms has provided highly sensitive molecular probes to determine clonality and lineage in lymphoproliferative lesions. The application of these probes to diagnostic problems in pathology has enhanced greatly the ability of the pathologist to determine clonality and lineage in lymphoid neoplasms, distinguish lymphoid from non-lymphoid tumors, monitor minimal residual disease, and identify early relapse.

Original languageEnglish (US)
Pages (from-to)119-149
Number of pages31
JournalClinics in Laboratory Medicine
Volume10
Issue number1
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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