TY - JOUR
T1 - Molecular genetic approaches for the diagnosis of clonality in lymphoid neoplasms
AU - Willman, C. L.
AU - Griffith, B. B.
AU - Whittaker, M.
PY - 1990
Y1 - 1990
N2 - The isolation of human DNA sequences that encode immunoglobulin genes, T cell receptor genes, and proto-oncogenes involved in the pathogenesis of lymphoid neoplasms has provided highly sensitive molecular probes to determine clonality and lineage in lymphoproliferative lesions. The application of these probes to diagnostic problems in pathology has enhanced greatly the ability of the pathologist to determine clonality and lineage in lymphoid neoplasms, distinguish lymphoid from non-lymphoid tumors, monitor minimal residual disease, and identify early relapse.
AB - The isolation of human DNA sequences that encode immunoglobulin genes, T cell receptor genes, and proto-oncogenes involved in the pathogenesis of lymphoid neoplasms has provided highly sensitive molecular probes to determine clonality and lineage in lymphoproliferative lesions. The application of these probes to diagnostic problems in pathology has enhanced greatly the ability of the pathologist to determine clonality and lineage in lymphoid neoplasms, distinguish lymphoid from non-lymphoid tumors, monitor minimal residual disease, and identify early relapse.
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U2 - 10.1016/s0272-2712(18)30585-7
DO - 10.1016/s0272-2712(18)30585-7
M3 - Review article
C2 - 2184975
AN - SCOPUS:0025274122
VL - 10
SP - 119
EP - 149
JO - Clinics in Laboratory Medicine
JF - Clinics in Laboratory Medicine
SN - 0272-2712
IS - 1
ER -