Molecular epidemiology of Escherichia coli sequence type 131 and its H30 and H30-Rx subclones among extended-spectrum-β-lactamase-positive and -negative E. coli clinical isolates from the Chicago region, 2007 to 2010

Ritu Banerjee, Ari Robicsek, Michael A. Kuskowski, Stephen Porter, Brian D. Johnston, Evgeni Sokurenko, Veronika Tchesnokova, Lance B. Price, James R. Johnson

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Abstract

We assessed Escherichia coli ST131 and its H30 and H30-Rx subclones for virulence genes, antimicrobial resistance, and extended-spectrum beta-lactamase (ESBL) type. Although both subclones were associated with ESBL production, H30-Rx isolates had higher resistance scores and were associated specifically with CTX-M-15. Three virulence genes (iha, sat, and iutA) were more prevalent among H30 than non-H30 ST131 isolates. Thus, the H30 and H30-Rx subclones are more antimicrobial resistant and have virulence profiles that are distinct from those of non-H30 ST131 isolates.

Original languageEnglish (US)
Pages (from-to)6385-6388
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume57
Issue number12
DOIs
StatePublished - Dec 2013

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Molecular Epidemiology
Virulence
beta-Lactamases
Escherichia coli
Genes

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

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Molecular epidemiology of Escherichia coli sequence type 131 and its H30 and H30-Rx subclones among extended-spectrum-β-lactamase-positive and -negative E. coli clinical isolates from the Chicago region, 2007 to 2010. / Banerjee, Ritu; Robicsek, Ari; Kuskowski, Michael A.; Porter, Stephen; Johnston, Brian D.; Sokurenko, Evgeni; Tchesnokova, Veronika; Price, Lance B.; Johnson, James R.

In: Antimicrobial Agents and Chemotherapy, Vol. 57, No. 12, 12.2013, p. 6385-6388.

Research output: Contribution to journalArticle

Banerjee, Ritu ; Robicsek, Ari ; Kuskowski, Michael A. ; Porter, Stephen ; Johnston, Brian D. ; Sokurenko, Evgeni ; Tchesnokova, Veronika ; Price, Lance B. ; Johnson, James R. / Molecular epidemiology of Escherichia coli sequence type 131 and its H30 and H30-Rx subclones among extended-spectrum-β-lactamase-positive and -negative E. coli clinical isolates from the Chicago region, 2007 to 2010. In: Antimicrobial Agents and Chemotherapy. 2013 ; Vol. 57, No. 12. pp. 6385-6388.
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AU - Johnston, Brian D.

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