Molecular determinants of lung cancer metastasis to the central nervous system

Timothy G. Whitsett, Landon J. Inge, Harshil D. Dhruv, Philip Y. Cheung, Glen J. Weiss, Ross M. Bremner, Jeffrey A. Winkles, Nhan Tran

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Lung cancer remains the leading cause of cancer-related mortality worldwide. The propensity for metastasis to the central nervous system (CNS) is a major clinical hurdle contributing to the low five-year survival rate of advanced disease. CNS metastases significantly outnumber primary brain tumors and carry a dismal prognosis in part due to the inability of therapeutic agents to cross the blood brain barrier. Standard treatment using radiation has been largely ineffective in improving mortality, suggesting the need for new agents targeting the critical metastatic drivers. The genetic and molecular events governing CNS metastasis from the lung are poorly understood at this time. This review highlights genetic events associated with CNS dissemination from the lung and molecular mechanisms associated with CNS metastasis. In vivo model systems that faithfully recapitulate escape from the lung and colonization of the CNS are described as tools for understanding the metastatic phenotype and for testing new therapeutic agents. A deeper understanding of the mechanisms of lung cancer metastasis to the CNS is needed to elucidate novel therapeutic avenues towards the improvement of the mortality associated with advanced stage lung cancer.

Original languageEnglish (US)
Pages (from-to)273-283
Number of pages11
JournalTranslational Lung Cancer Research
Volume2
Issue number4
DOIs
StatePublished - 2013
Externally publishedYes

Fingerprint

Lung Neoplasms
Central Nervous System
Neoplasm Metastasis
Lung
Mortality
Blood-Brain Barrier
Brain Neoplasms
Molecular Biology
Therapeutics
Survival Rate
Radiation
Phenotype
Neoplasms

Keywords

  • CNS metastases
  • Lung cancer
  • Molecular determinants

ASJC Scopus subject areas

  • Oncology

Cite this

Molecular determinants of lung cancer metastasis to the central nervous system. / Whitsett, Timothy G.; Inge, Landon J.; Dhruv, Harshil D.; Cheung, Philip Y.; Weiss, Glen J.; Bremner, Ross M.; Winkles, Jeffrey A.; Tran, Nhan.

In: Translational Lung Cancer Research, Vol. 2, No. 4, 2013, p. 273-283.

Research output: Contribution to journalReview article

Whitsett, TG, Inge, LJ, Dhruv, HD, Cheung, PY, Weiss, GJ, Bremner, RM, Winkles, JA & Tran, N 2013, 'Molecular determinants of lung cancer metastasis to the central nervous system', Translational Lung Cancer Research, vol. 2, no. 4, pp. 273-283. https://doi.org/10.3978/j.issn.2218-6751.2013.03.12
Whitsett, Timothy G. ; Inge, Landon J. ; Dhruv, Harshil D. ; Cheung, Philip Y. ; Weiss, Glen J. ; Bremner, Ross M. ; Winkles, Jeffrey A. ; Tran, Nhan. / Molecular determinants of lung cancer metastasis to the central nervous system. In: Translational Lung Cancer Research. 2013 ; Vol. 2, No. 4. pp. 273-283.
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