Molecular determinants of calpain-dependent cleavage of junctophilin-2 protein in cardiomyocytes

Ang Guo, Duane Hall, Caimei Zhang, Tianqing Peng, Jordan D. Miller, William Kutschke, Chad E. Grueter, Frances L. Johnson, Richard Z. Lin, Long Sheng Song

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Background: Down-regulation of junctophilin-2 is associated with a variety of cardiac diseases. Results: Junctophilin-2 is cleaved by calpain at multiple sites, resulting in dysfunctional junctophilin-2 truncations. Conclusion: Calpain-mediated proteolysis contributes to posttranslational down-regulation of junctophilin-2. Significance: These data reveal, for the first time, the detailed molecular determinants responsible for calpain proteolysis of junctophilin-2.

Original languageEnglish (US)
Pages (from-to)17946-17955
Number of pages10
JournalJournal of Biological Chemistry
Volume290
Issue number29
DOIs
StatePublished - Jul 17 2015

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Guo, A., Hall, D., Zhang, C., Peng, T., Miller, J. D., Kutschke, W., Grueter, C. E., Johnson, F. L., Lin, R. Z., & Song, L. S. (2015). Molecular determinants of calpain-dependent cleavage of junctophilin-2 protein in cardiomyocytes. Journal of Biological Chemistry, 290(29), 17946-17955. https://doi.org/10.1074/jbc.M115.652396