Molecular detection of pancreatic neoplasia: Current status and future promise

Shounak Majumder, Suresh T. Chari, David A. Ahlquist

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Pancreatic cancer is usually diagnosed at an advanced stage and curative resection is feasible in only a small minority of patients at the time of diagnosis. Diagnosis at an early stage is unequivocally associated with better long-term survival. Several candidate molecular markers for early detection are currently under investigation in different phases of discovery and validation. Recent advances in the technology for whole genome, methylome, ribonucleome, and proteome interrogation has enabled rapid advancements in the field of biomarker discovery. In this review we discuss the current status of molecular markers for detection of pancreatic cancer in blood, pancreatic cyst fluid, pancreatic juice and stool and briefly highlight some promising preliminary results of new approaches that have the potential of advancing this field in the near future.

Original languageEnglish (US)
Pages (from-to)11387-11395
Number of pages9
JournalWorld journal of gastroenterology
Volume21
Issue number40
DOIs
StatePublished - Oct 28 2015

Keywords

  • Biomarkers
  • Early detection of cancer
  • Methylation
  • Pancreatic cancer
  • Pancreatic cyst fluid
  • Pancreatic juice
  • Sensitivity and specificity
  • Stool

ASJC Scopus subject areas

  • Gastroenterology

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