Molecular Biomarkers for the Evaluation of Colorectal Cancer

Antonia R. Sepulveda; Stanley R. Hamilton; Carmen J. Allegra; Wayne Grody; Allison M. Cushman-Vokoun; William K. Funkhouser; Scott E. Kopetz; Christopher Lieu; Noralane M. Lindor; Bruce D. Minsky; Federico A. Monzon; Daniel J. Sargent; Veena M. Singh; Joseph Willis; Jennifer Clark; Carol Colasacco; R. Bryan Rumble; Robyn Temple-Smolkin; Christina B. Ventura; Jan A. Nowak

doi:10.1093/ajcp/aqw209

Molecular Biomarkers for the Evaluation of Colorectal Cancer

Antonia R. Sepulveda, Stanley R. Hamilton, Carmen J. Allegra, Wayne Grody, Allison M. Cushman-Vokoun, William K. Funkhouser, Scott E. Kopetz, Christopher Lieu, Noralane M. Lindor, Bruce D. Minsky, Federico A. Monzon, Daniel J. Sargent, Veena M. Singh, Joseph Willis, Jennifer Clark, Carol Colasacco, R. Bryan Rumble, Robyn Temple-Smolkin, Christina B. Ventura, Jan A. Nowak

Research output: Contribution to journal › Article

10 Scopus citations

Abstract

Objectives: To develop evidence-based guideline recommendations through a systematic review of the literature to establish standard molecular biomarker testing of colorectal cancer (CRC) tissues to guide epidermal growth factor receptor (EGFR) therapies and conventional chemotherapy regimens. Methods: The American Society for Clinical Pathology, College of American Pathologists, Association for Molecular Pathology, and American Society of Clinical Oncology convened an expert panel to develop an evidence-based guideline to establish standard molecular biomarker testing and guide therapies for patients with CRC. A comprehensive literature search that included more than 4,000 articles was conducted. Results: Twenty-one guideline statements were established. Conclusions: Evidence supports mutational testing for EGFR signaling pathway genes, since they provide clinically actionable information as negative predictors of benefit to anti-EGFR monoclonal antibody therapies for targeted therapy of CRC. Mutations in several of the biomarkers have clear prognostic value. Laboratory approaches to operationalize CRC molecular testing are presented.

Original language	English (US)
Pages (from-to)	221-260
Number of pages	40
Journal	American journal of clinical pathology
Volume	147
Issue number	3
DOIs	https://doi.org/10.1093/ajcp/aqw209
State	Published - Mar 1 2017

Keywords

Molecular diagnostics
gastrointestinal
genetics
histology
oncology

ASJC Scopus subject areas

Pathology and Forensic Medicine

Access to Document

10.1093/ajcp/aqw209

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Sepulveda, A. R., Hamilton, S. R., Allegra, C. J., Grody, W., Cushman-Vokoun, A. M., Funkhouser, W. K., Kopetz, S. E., Lieu, C., Lindor, N. M., Minsky, B. D., Monzon, F. A., Sargent, D. J., Singh, V. M., Willis, J., Clark, J., Colasacco, C., Rumble, R. B., Temple-Smolkin, R., Ventura, C. B., & Nowak, J. A. (2017). Molecular Biomarkers for the Evaluation of Colorectal Cancer. American journal of clinical pathology, 147(3), 221-260. https://doi.org/10.1093/ajcp/aqw209

Molecular Biomarkers for the Evaluation of Colorectal Cancer. / Sepulveda, Antonia R.; Hamilton, Stanley R.; Allegra, Carmen J.; Grody, Wayne; Cushman-Vokoun, Allison M.; Funkhouser, William K.; Kopetz, Scott E.; Lieu, Christopher; Lindor, Noralane M.; Minsky, Bruce D.; Monzon, Federico A.; Sargent, Daniel J.; Singh, Veena M.; Willis, Joseph; Clark, Jennifer; Colasacco, Carol; Rumble, R. Bryan; Temple-Smolkin, Robyn; Ventura, Christina B.; Nowak, Jan A.

In: American journal of clinical pathology, Vol. 147, No. 3, 01.03.2017, p. 221-260.

Research output: Contribution to journal › Article

Sepulveda, AR, Hamilton, SR, Allegra, CJ, Grody, W, Cushman-Vokoun, AM, Funkhouser, WK, Kopetz, SE, Lieu, C, Lindor, NM, Minsky, BD, Monzon, FA, Sargent, DJ, Singh, VM, Willis, J, Clark, J, Colasacco, C, Rumble, RB, Temple-Smolkin, R, Ventura, CB & Nowak, JA 2017, 'Molecular Biomarkers for the Evaluation of Colorectal Cancer', American journal of clinical pathology, vol. 147, no. 3, pp. 221-260. https://doi.org/10.1093/ajcp/aqw209

Sepulveda, Antonia R. ; Hamilton, Stanley R. ; Allegra, Carmen J. ; Grody, Wayne ; Cushman-Vokoun, Allison M. ; Funkhouser, William K. ; Kopetz, Scott E. ; Lieu, Christopher ; Lindor, Noralane M. ; Minsky, Bruce D. ; Monzon, Federico A. ; Sargent, Daniel J. ; Singh, Veena M. ; Willis, Joseph ; Clark, Jennifer ; Colasacco, Carol ; Rumble, R. Bryan ; Temple-Smolkin, Robyn ; Ventura, Christina B. ; Nowak, Jan A. / Molecular Biomarkers for the Evaluation of Colorectal Cancer. In: American journal of clinical pathology. 2017 ; Vol. 147, No. 3. pp. 221-260.

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abstract = "Objectives: To develop evidence-based guideline recommendations through a systematic review of the literature to establish standard molecular biomarker testing of colorectal cancer (CRC) tissues to guide epidermal growth factor receptor (EGFR) therapies and conventional chemotherapy regimens. Methods: The American Society for Clinical Pathology, College of American Pathologists, Association for Molecular Pathology, and American Society of Clinical Oncology convened an expert panel to develop an evidence-based guideline to establish standard molecular biomarker testing and guide therapies for patients with CRC. A comprehensive literature search that included more than 4,000 articles was conducted. Results: Twenty-one guideline statements were established. Conclusions: Evidence supports mutational testing for EGFR signaling pathway genes, since they provide clinically actionable information as negative predictors of benefit to anti-EGFR monoclonal antibody therapies for targeted therapy of CRC. Mutations in several of the biomarkers have clear prognostic value. Laboratory approaches to operationalize CRC molecular testing are presented.",

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AU - Minsky, Bruce D.

AU - Monzon, Federico A.

AU - Sargent, Daniel J.

AU - Singh, Veena M.

AU - Willis, Joseph

AU - Clark, Jennifer

AU - Colasacco, Carol

AU - Rumble, R. Bryan

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AU - Ventura, Christina B.

AU - Nowak, Jan A.

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