Molecular approaches for colorectal cancer screening

Jin Jen, Constance Johnson, Bernard Levin

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Molecular genetic approaches for colorectal cancer screening using stool samples have the potential to be very specific, sensitive and cost effective. K-ras oncogene mutation, observed in about 50% of the colorectal tumours, serves as an ideal target for such an approach. Several studies have shown that K-ras gene mutations present in the tumours can be detected from the stool of patients with colorectal cancer. The challenge for clinical application, however, is to develop a simple method for robust PCR amplification and a reliable assay for K-ras gene mutation detection in the stool samples.

Original languageEnglish (US)
Pages (from-to)213-217
Number of pages5
JournalEuropean Journal of Gastroenterology and Hepatology
Volume10
Issue number3
DOIs
StatePublished - 1998

Keywords

  • Aberrant crypt foci
  • Colorectal cancer screening
  • Early diagnosis
  • K-ras mutation
  • Mis-match ligation assay
  • PCR
  • Stool DNA purification

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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