Molecular abnormalities in colorectal cancer: Microsatellite instability pathway

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The expansion and contraction of microsatellite DNA in colon cancer (microsatellite instability) has provided the first strong experimental support for a mutator phenotype in cancer. As a result of this and other key observations, several human DNA mismatch repair genes, in particular hMLH1 and hMSH2, have now been implicated in this process. Tumors harboring such a mutator phenotype appear to have distinctive genetic, pathologic, and clinical characteristics.

Original languageEnglish (US)
Pages (from-to)38-48
Number of pages11
JournalSeminars in Colon and Rectal Surgery
Volume9
Issue number1
StatePublished - Jan 1 1998

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

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