Molecular abnormalities in colorectal cancer: Microsatellite instability pathway

J. M. Cunningham; L. A. Boardman; L. J. Burgart; S. N. Thibodeau

Molecular abnormalities in colorectal cancer: Microsatellite instability pathway

J. M. Cunningham, L. A. Boardman, L. J. Burgart, S. N. Thibodeau

Research output: Contribution to journal › Article › peer-review

Abstract

The expansion and contraction of microsatellite DNA in colon cancer (microsatellite instability) has provided the first strong experimental support for a mutator phenotype in cancer. As a result of this and other key observations, several human DNA mismatch repair genes, in particular hMLH1 and hMSH2, have now been implicated in this process. Tumors harboring such a mutator phenotype appear to have distinctive genetic, pathologic, and clinical characteristics.

Original language	English (US)
Pages (from-to)	38-48
Number of pages	11
Journal	Seminars in Colon and Rectal Surgery
Volume	9
Issue number	1
State	Published - 1998

ASJC Scopus subject areas

Surgery
Gastroenterology

Cite this

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title = "Molecular abnormalities in colorectal cancer: Microsatellite instability pathway",

abstract = "The expansion and contraction of microsatellite DNA in colon cancer (microsatellite instability) has provided the first strong experimental support for a mutator phenotype in cancer. As a result of this and other key observations, several human DNA mismatch repair genes, in particular hMLH1 and hMSH2, have now been implicated in this process. Tumors harboring such a mutator phenotype appear to have distinctive genetic, pathologic, and clinical characteristics.",

author = "Cunningham, {J. M.} and Boardman, {L. A.} and Burgart, {L. J.} and Thibodeau, {S. N.}",

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PY - 1998

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N2 - The expansion and contraction of microsatellite DNA in colon cancer (microsatellite instability) has provided the first strong experimental support for a mutator phenotype in cancer. As a result of this and other key observations, several human DNA mismatch repair genes, in particular hMLH1 and hMSH2, have now been implicated in this process. Tumors harboring such a mutator phenotype appear to have distinctive genetic, pathologic, and clinical characteristics.

AB - The expansion and contraction of microsatellite DNA in colon cancer (microsatellite instability) has provided the first strong experimental support for a mutator phenotype in cancer. As a result of this and other key observations, several human DNA mismatch repair genes, in particular hMLH1 and hMSH2, have now been implicated in this process. Tumors harboring such a mutator phenotype appear to have distinctive genetic, pathologic, and clinical characteristics.

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Molecular abnormalities in colorectal cancer: Microsatellite instability pathway

Abstract

ASJC Scopus subject areas

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