The expansion and contraction of microsatellite DNA in colon cancer (microsatellite instability) has provided the first strong experimental support for a mutator phenotype in cancer. As a result of this and other key observations, several human DNA mismatch repair genes, in particular hMLH1 and hMSH2, have now been implicated in this process. Tumors harboring such a mutator phenotype appear to have distinctive genetic, pathologic, and clinical characteristics.
|Original language||English (US)|
|Number of pages||11|
|Journal||Seminars in Colon and Rectal Surgery|
|State||Published - Jan 1 1998|
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