MOG-IgG myelitis coexisting with systemic lupus erythematosus in the post-partum setting

Philippe A. Bilodeau, Vinayak Kumar, Andrew E. Rodriguez, Clarence T. Li, Catalina Sanchez-Alvarez, Uma Thanarajasingam, Nicholas L. Zalewski, Eoin P. Flanagan

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Background: Longitudinally extensive transverse myelitis (LETM) accompanying systemic lupus erythematosus (SLE) is often due to coexisting aquaporin-4-IgG seropositive neuromyelitis optica spectrum disorder but has not been associated with myelin oligodendrocyte glycoprotein-IgG (MOG-IgG). Objective and methods: Case report at an academic medical center. Results: A 32-year-old woman developed severe transverse myelitis (paraplegia) shortly after SLE onset in the post-partum period. Magnetic resonance imaging (MRI) revealed an LETM, cerebrospinal fluid showed marked inflammation, and testing for infections was negative. Serum live-cell-based assay for MOG-IgG was positive but aquaporin-4-IgG was negative. Conclusion: In patients with SLE and LETM, MOG-IgG testing should be considered, in addition to AQP4-IgG.

Original languageEnglish (US)
Pages (from-to)997-1000
Number of pages4
JournalMultiple Sclerosis Journal
Volume26
Issue number8
DOIs
StatePublished - Jul 1 2020

Keywords

  • MOG
  • SLE
  • Transverse myelitis
  • myelin oligodendrocyte glycoprotein

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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