MOG-IgG myelitis coexisting with systemic lupus erythematosus in the post-partum setting

Philippe A. Bilodeau, Vinayak Kumar, Andrew E. Rodriguez, Clarence T. Li, Catalina Sanchez-Alvarez, Uma Thanarajasingam, Nicholas L. Zalewski, Eoin P. Flanagan

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Abstract

Background: Longitudinally extensive transverse myelitis (LETM) accompanying systemic lupus erythematosus (SLE) is often due to coexisting aquaporin-4-IgG seropositive neuromyelitis optica spectrum disorder but has not been associated with myelin oligodendrocyte glycoprotein-IgG (MOG-IgG). Objective and methods: Case report at an academic medical center. Results: A 32-year-old woman developed severe transverse myelitis (paraplegia) shortly after SLE onset in the post-partum period. Magnetic resonance imaging (MRI) revealed an LETM, cerebrospinal fluid showed marked inflammation, and testing for infections was negative. Serum live-cell-based assay for MOG-IgG was positive but aquaporin-4-IgG was negative. Conclusion: In patients with SLE and LETM, MOG-IgG testing should be considered, in addition to AQP4-IgG.

Original languageEnglish (US)
JournalMultiple Sclerosis Journal
DOIs
StateAccepted/In press - Jan 1 2019

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Keywords

  • MOG
  • myelin oligodendrocyte glycoprotein
  • SLE
  • Transverse myelitis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Bilodeau, P. A., Kumar, V., Rodriguez, A. E., Li, C. T., Sanchez-Alvarez, C., Thanarajasingam, U., Zalewski, N. L., & Flanagan, E. P. (Accepted/In press). MOG-IgG myelitis coexisting with systemic lupus erythematosus in the post-partum setting. Multiple Sclerosis Journal. https://doi.org/10.1177/1352458519872895