TY - JOUR
T1 - MOG-IgG myelitis coexisting with systemic lupus erythematosus in the post-partum setting
AU - Bilodeau, Philippe A.
AU - Kumar, Vinayak
AU - Rodriguez, Andrew E.
AU - Li, Clarence T.
AU - Sanchez-Alvarez, Catalina
AU - Thanarajasingam, Uma
AU - Zalewski, Nicholas L.
AU - Flanagan, Eoin P.
N1 - Publisher Copyright:
© The Author(s), 2019.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Background: Longitudinally extensive transverse myelitis (LETM) accompanying systemic lupus erythematosus (SLE) is often due to coexisting aquaporin-4-IgG seropositive neuromyelitis optica spectrum disorder but has not been associated with myelin oligodendrocyte glycoprotein-IgG (MOG-IgG). Objective and methods: Case report at an academic medical center. Results: A 32-year-old woman developed severe transverse myelitis (paraplegia) shortly after SLE onset in the post-partum period. Magnetic resonance imaging (MRI) revealed an LETM, cerebrospinal fluid showed marked inflammation, and testing for infections was negative. Serum live-cell-based assay for MOG-IgG was positive but aquaporin-4-IgG was negative. Conclusion: In patients with SLE and LETM, MOG-IgG testing should be considered, in addition to AQP4-IgG.
AB - Background: Longitudinally extensive transverse myelitis (LETM) accompanying systemic lupus erythematosus (SLE) is often due to coexisting aquaporin-4-IgG seropositive neuromyelitis optica spectrum disorder but has not been associated with myelin oligodendrocyte glycoprotein-IgG (MOG-IgG). Objective and methods: Case report at an academic medical center. Results: A 32-year-old woman developed severe transverse myelitis (paraplegia) shortly after SLE onset in the post-partum period. Magnetic resonance imaging (MRI) revealed an LETM, cerebrospinal fluid showed marked inflammation, and testing for infections was negative. Serum live-cell-based assay for MOG-IgG was positive but aquaporin-4-IgG was negative. Conclusion: In patients with SLE and LETM, MOG-IgG testing should be considered, in addition to AQP4-IgG.
KW - MOG
KW - SLE
KW - Transverse myelitis
KW - myelin oligodendrocyte glycoprotein
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U2 - 10.1177/1352458519872895
DO - 10.1177/1352458519872895
M3 - Article
C2 - 31621483
AN - SCOPUS:85074356287
SN - 1352-4585
VL - 26
SP - 997
EP - 1000
JO - Multiple Sclerosis Journal
JF - Multiple Sclerosis Journal
IS - 8
ER -