Modulation of transforming growth factor type beta action by activated ras and c-myc.

Edward B Leof, J. A. Proper, H. L. Moses

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Transfection of C3H/10T1/2 cells with a c-myc gene resulted in the acquisition of responsiveness to transforming growth factor type beta. Cells transfected with an activated H-ras gene or an H-ras and c-myc gene, however, exhibited a transformed morphology and spontaneous soft-agar growth, a phenotype induced reversibly by transforming growth factor type beta in responsive fibroblasts.

Original languageEnglish (US)
Pages (from-to)2649-2652
Number of pages4
JournalMolecular and Cellular Biology
Volume7
Issue number7
StatePublished - Jul 1987
Externally publishedYes

Fingerprint

myc Genes
Transforming Growth Factor beta
ras Genes
Agar
Transfection
Fibroblasts
Phenotype
Growth

ASJC Scopus subject areas

  • Cell Biology
  • Genetics
  • Molecular Biology

Cite this

Modulation of transforming growth factor type beta action by activated ras and c-myc. / Leof, Edward B; Proper, J. A.; Moses, H. L.

In: Molecular and Cellular Biology, Vol. 7, No. 7, 07.1987, p. 2649-2652.

Research output: Contribution to journalArticle

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