Modulation of transforming growth factor type beta action by activated ras and c-myc.

E. B. Leof, J. A. Proper, H. L. Moses

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Abstract

Transfection of C3H/10T1/2 cells with a c-myc gene resulted in the acquisition of responsiveness to transforming growth factor type beta. Cells transfected with an activated H-ras gene or an H-ras and c-myc gene, however, exhibited a transformed morphology and spontaneous soft-agar growth, a phenotype induced reversibly by transforming growth factor type beta in responsive fibroblasts.

Original languageEnglish (US)
Pages (from-to)2649-2652
Number of pages4
JournalMolecular and cellular biology
Volume7
Issue number7
DOIs
StatePublished - Jul 1987

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ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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