Modulation of the formation of adhesions during the healing of injured tendons

U. Khan, Sanjeev Kakar, A. Akali, G. Bentley, D. A. McGrouther

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The formation of restrictive adhesions around the musculotendinous unit after injury is one of the most vexing processes faced by the surgeon. In flexor tendons it has been shown that the synovial tissue is the source of aggressive fibroblasts which contribute to this process. Using a rabbit model, we have examined the effects of treating the synovial sheath with the antimetabolite 5-fluorouracil (5-FU) for five minutes. Inflammatory, proliferative and molecular markers were compared in the response of the treated and control tendons to injury. Compared with a control group we found that the proliferative and inflammatory responses were significantly reduced (p < 0.001) in the treated tendons. Not only was there a reduction in the cellular and cytokine response, but there also was a significant (p < 0.001) reduction in the level of activity of the known pro-scarring agent, transforming growth factor beta 1 (TGF-β1). These pilot studies indicate that the formation of restrictive adhesions may be modulated using a simple single-touch technique in the hope of producing a better return of function.

Original languageEnglish (US)
Pages (from-to)1054-1058
Number of pages5
JournalJournal of Bone and Joint Surgery - Series B
Volume82
Issue number7
StatePublished - 2000
Externally publishedYes

Fingerprint

Tendons
Tendon Injuries
Antimetabolites
Touch
Fluorouracil
Transforming Growth Factor beta
Cicatrix
Fibroblasts
Cytokines
Rabbits
Control Groups
Wounds and Injuries
Surgeons

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

Cite this

Modulation of the formation of adhesions during the healing of injured tendons. / Khan, U.; Kakar, Sanjeev; Akali, A.; Bentley, G.; McGrouther, D. A.

In: Journal of Bone and Joint Surgery - Series B, Vol. 82, No. 7, 2000, p. 1054-1058.

Research output: Contribution to journalArticle

Khan, U, Kakar, S, Akali, A, Bentley, G & McGrouther, DA 2000, 'Modulation of the formation of adhesions during the healing of injured tendons', Journal of Bone and Joint Surgery - Series B, vol. 82, no. 7, pp. 1054-1058.
Khan, U. ; Kakar, Sanjeev ; Akali, A. ; Bentley, G. ; McGrouther, D. A. / Modulation of the formation of adhesions during the healing of injured tendons. In: Journal of Bone and Joint Surgery - Series B. 2000 ; Vol. 82, No. 7. pp. 1054-1058.
@article{65558f37670d4778a95a6dbb77559fa7,
title = "Modulation of the formation of adhesions during the healing of injured tendons",
abstract = "The formation of restrictive adhesions around the musculotendinous unit after injury is one of the most vexing processes faced by the surgeon. In flexor tendons it has been shown that the synovial tissue is the source of aggressive fibroblasts which contribute to this process. Using a rabbit model, we have examined the effects of treating the synovial sheath with the antimetabolite 5-fluorouracil (5-FU) for five minutes. Inflammatory, proliferative and molecular markers were compared in the response of the treated and control tendons to injury. Compared with a control group we found that the proliferative and inflammatory responses were significantly reduced (p < 0.001) in the treated tendons. Not only was there a reduction in the cellular and cytokine response, but there also was a significant (p < 0.001) reduction in the level of activity of the known pro-scarring agent, transforming growth factor beta 1 (TGF-β1). These pilot studies indicate that the formation of restrictive adhesions may be modulated using a simple single-touch technique in the hope of producing a better return of function.",
author = "U. Khan and Sanjeev Kakar and A. Akali and G. Bentley and McGrouther, {D. A.}",
year = "2000",
language = "English (US)",
volume = "82",
pages = "1054--1058",
journal = "Bone and Joint Journal",
issn = "2049-4394",
publisher = "British Editorial Society of Bone and Joint Surgery",
number = "7",

}

TY - JOUR

T1 - Modulation of the formation of adhesions during the healing of injured tendons

AU - Khan, U.

AU - Kakar, Sanjeev

AU - Akali, A.

AU - Bentley, G.

AU - McGrouther, D. A.

PY - 2000

Y1 - 2000

N2 - The formation of restrictive adhesions around the musculotendinous unit after injury is one of the most vexing processes faced by the surgeon. In flexor tendons it has been shown that the synovial tissue is the source of aggressive fibroblasts which contribute to this process. Using a rabbit model, we have examined the effects of treating the synovial sheath with the antimetabolite 5-fluorouracil (5-FU) for five minutes. Inflammatory, proliferative and molecular markers were compared in the response of the treated and control tendons to injury. Compared with a control group we found that the proliferative and inflammatory responses were significantly reduced (p < 0.001) in the treated tendons. Not only was there a reduction in the cellular and cytokine response, but there also was a significant (p < 0.001) reduction in the level of activity of the known pro-scarring agent, transforming growth factor beta 1 (TGF-β1). These pilot studies indicate that the formation of restrictive adhesions may be modulated using a simple single-touch technique in the hope of producing a better return of function.

AB - The formation of restrictive adhesions around the musculotendinous unit after injury is one of the most vexing processes faced by the surgeon. In flexor tendons it has been shown that the synovial tissue is the source of aggressive fibroblasts which contribute to this process. Using a rabbit model, we have examined the effects of treating the synovial sheath with the antimetabolite 5-fluorouracil (5-FU) for five minutes. Inflammatory, proliferative and molecular markers were compared in the response of the treated and control tendons to injury. Compared with a control group we found that the proliferative and inflammatory responses were significantly reduced (p < 0.001) in the treated tendons. Not only was there a reduction in the cellular and cytokine response, but there also was a significant (p < 0.001) reduction in the level of activity of the known pro-scarring agent, transforming growth factor beta 1 (TGF-β1). These pilot studies indicate that the formation of restrictive adhesions may be modulated using a simple single-touch technique in the hope of producing a better return of function.

UR - http://www.scopus.com/inward/record.url?scp=0033825443&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033825443&partnerID=8YFLogxK

M3 - Article

VL - 82

SP - 1054

EP - 1058

JO - Bone and Joint Journal

JF - Bone and Joint Journal

SN - 2049-4394

IS - 7

ER -