Modulation of apoptosis by HIV protease inhibitors

B. N. Phenix, C. Cooper, C. Owen, A. D. Badley

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

Advances in treatment have transformed the Human Immunodeficiency Virus (HIV) infection from a progressive and ultimately fatal disease to one that can be managed effectively by chronic suppressive antiretroviral therapy. The drugs now used to treat HIV infection not only inhibit viral replication but also have effects on cellular metabolism and homeostasis. Of particular interest to cellular immunologists, members of the HIV Protease Inhibitor (PI) class of antiretroviral agents possess intrinsic immunomodulatory and antiapoptotic properties. This review focuses on the development and use of PI together with their impact on HIV disease, immunity, and apoptosis.

Original languageEnglish (US)
Pages (from-to)295-312
Number of pages18
JournalApoptosis
Volume7
Issue number4
DOIs
StatePublished - Aug 12 2002

Keywords

  • Apoptosis
  • CD4 T cell
  • HIV
  • Immunity
  • Protease inhibitor

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Cancer Research

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