Modulation of apoptosis by HIV protease inhibitors

B. N. Phenix; C. Cooper; C. Owen; A. D. Badley

doi:10.1023/A:1016168411221

Modulation of apoptosis by HIV protease inhibitors

B. N. Phenix, C. Cooper, C. Owen, A. D. Badley

Infectious Diseases

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

Advances in treatment have transformed the Human Immunodeficiency Virus (HIV) infection from a progressive and ultimately fatal disease to one that can be managed effectively by chronic suppressive antiretroviral therapy. The drugs now used to treat HIV infection not only inhibit viral replication but also have effects on cellular metabolism and homeostasis. Of particular interest to cellular immunologists, members of the HIV Protease Inhibitor (PI) class of antiretroviral agents possess intrinsic immunomodulatory and antiapoptotic properties. This review focuses on the development and use of PI together with their impact on HIV disease, immunity, and apoptosis.

Original language	English (US)
Pages (from-to)	295-312
Number of pages	18
Journal	Apoptosis
Volume	7
Issue number	4
DOIs	https://doi.org/10.1023/A:1016168411221
State	Published - 2002

Keywords

Apoptosis
CD4 T cell
HIV
Immunity
Protease inhibitor

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science
Clinical Biochemistry
Cell Biology
Biochemistry, medical
Cancer Research

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10.1023/A:1016168411221

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title = "Modulation of apoptosis by HIV protease inhibitors",

abstract = "Advances in treatment have transformed the Human Immunodeficiency Virus (HIV) infection from a progressive and ultimately fatal disease to one that can be managed effectively by chronic suppressive antiretroviral therapy. The drugs now used to treat HIV infection not only inhibit viral replication but also have effects on cellular metabolism and homeostasis. Of particular interest to cellular immunologists, members of the HIV Protease Inhibitor (PI) class of antiretroviral agents possess intrinsic immunomodulatory and antiapoptotic properties. This review focuses on the development and use of PI together with their impact on HIV disease, immunity, and apoptosis.",

keywords = "Apoptosis, CD4 T cell, HIV, Immunity, Protease inhibitor",

author = "Phenix, {B. N.} and C. Cooper and C. Owen and Badley, {A. D.}",

note = "Funding Information: ADB is supported by grants from the Positive Action Fund of the Ontario Ministry of Health, Canadian Institutes of Health Research (CIHR), Canadian Foundation for AIDS Research (CANFAR) and the Doris Duke Charitable Foundation. ADB is a Career Scientist Award recipient from the Ontario HIV Treatment Network (OHTN), BNP has received a Studentship Award from the OHTN. The authors gratefully acknowledge the administrative expertise of A. Carisse, and the editorial review of Dr. B.W.D. Badley.",

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doi = "10.1023/A:1016168411221",

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T1 - Modulation of apoptosis by HIV protease inhibitors

AU - Phenix, B. N.

AU - Cooper, C.

AU - Owen, C.

AU - Badley, A. D.

N1 - Funding Information: ADB is supported by grants from the Positive Action Fund of the Ontario Ministry of Health, Canadian Institutes of Health Research (CIHR), Canadian Foundation for AIDS Research (CANFAR) and the Doris Duke Charitable Foundation. ADB is a Career Scientist Award recipient from the Ontario HIV Treatment Network (OHTN), BNP has received a Studentship Award from the OHTN. The authors gratefully acknowledge the administrative expertise of A. Carisse, and the editorial review of Dr. B.W.D. Badley.

PY - 2002

Y1 - 2002

N2 - Advances in treatment have transformed the Human Immunodeficiency Virus (HIV) infection from a progressive and ultimately fatal disease to one that can be managed effectively by chronic suppressive antiretroviral therapy. The drugs now used to treat HIV infection not only inhibit viral replication but also have effects on cellular metabolism and homeostasis. Of particular interest to cellular immunologists, members of the HIV Protease Inhibitor (PI) class of antiretroviral agents possess intrinsic immunomodulatory and antiapoptotic properties. This review focuses on the development and use of PI together with their impact on HIV disease, immunity, and apoptosis.

AB - Advances in treatment have transformed the Human Immunodeficiency Virus (HIV) infection from a progressive and ultimately fatal disease to one that can be managed effectively by chronic suppressive antiretroviral therapy. The drugs now used to treat HIV infection not only inhibit viral replication but also have effects on cellular metabolism and homeostasis. Of particular interest to cellular immunologists, members of the HIV Protease Inhibitor (PI) class of antiretroviral agents possess intrinsic immunomodulatory and antiapoptotic properties. This review focuses on the development and use of PI together with their impact on HIV disease, immunity, and apoptosis.

KW - Apoptosis

KW - CD4 T cell

KW - HIV

KW - Immunity

KW - Protease inhibitor

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Modulation of apoptosis by HIV protease inhibitors

Abstract

Keywords

ASJC Scopus subject areas

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