Modulation of agonist and antagonist interactions in serotonin 1A receptors by alcohols

K. G. Harikumar, Amitabha Chattopadhyay

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

The serotonin type 1A (5-HT(1A)) receptors are members of a superfamily of seven transmembrane domain receptors that couple to GTP binding regulatory proteins (G-proteins). Serotonergic signalling has been shown to play an important role in alcohol tolerance and dependence. We have studied the effects of alcohols on ligand (agonist and antagonist) binding to bovine hippocampal 5-HT(1A) receptor in native as well as solubilized membranes. Our results show that alcohols inhibit the specific binding of the agonist OH-DPAT and the antagonist p-MPPF to 5-HT(1A) receptors in a concentration-dependent manner. Copyright (C) 1998 Federation of European Biochemical Societies.

Original languageEnglish (US)
Pages (from-to)96-100
Number of pages5
JournalFEBS Letters
Volume438
Issue number1-2
DOIs
StatePublished - Oct 30 1998

Keywords

  • 4-(2'-Methoxy)-phenyl-1-[2'-(N-2''-pyridinyl)-p-fluorobenzamido]ethyl-piperazine
  • 4-(2'-Methoxy)-phenyl-1-[2'-(N-2''-pyridinyl)-p-iodobenzamido]ethyl-piperazine
  • 8-Hydroxy-2-(di-N-propylamino)tetralin
  • Alcohol
  • Bovine hippocampus
  • Serotonin 1A receptor

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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