Modulating pharmacokinetics, tumor uptake and biodistribution by engineered nanoparticles

Rochelle R. Arvizo, Oscar R. Miranda, Daniel F. Moyano, Chad A. Walden, Karuna Giri, Resham Bhattacharya, J. David Robertson, Vincent M. Rotello, Joel M. Reid, Priyabrata Mukherjee

Research output: Contribution to journalArticle

194 Scopus citations

Abstract

Background: Inorganic nanoparticles provide promising tools for biomedical applications including detection, diagnosis and therapy. While surface properties such as charge are expected to play an important role in their in vivo behavior, very little is known how the surface chemistry of nanoparticles influences their pharmacokinetics, tumor uptake, and biodistribution. Method/Principal Findings: Using a family of structurally homologous nanoparticles we have investigated how pharmacological properties including tumor uptake and biodistribution are influenced by surface charge using neutral (TEGOH), zwitterionic (Tzwit), negative (TCOOH) and positive (TTMA) nanoparticles. Nanoparticles were injected into mice (normal and athymic) either in the tail vein or into the peritoneum. Conclusion: Neutral and zwitterionic nanoparticles demonstrated longer circulation time via both IP and IV administration, whereas negatively and positively charged nanoparticles possessed relatively short half-lives. These pharmacological characteristics were reflected on the tumor uptake and biodistribution of the respective nanoparticles, with enhanced tumor uptake by neutral and zwitterionic nanoparticles via passive targeting.

Original languageEnglish (US)
Article numbere24374
JournalPloS one
Volume6
Issue number9
DOIs
StatePublished - Sep 13 2011

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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    Arvizo, R. R., Miranda, O. R., Moyano, D. F., Walden, C. A., Giri, K., Bhattacharya, R., Robertson, J. D., Rotello, V. M., Reid, J. M., & Mukherjee, P. (2011). Modulating pharmacokinetics, tumor uptake and biodistribution by engineered nanoparticles. PloS one, 6(9), [e24374]. https://doi.org/10.1371/journal.pone.0024374