Modulating kidney transplant interstitial fibrosis and tubular atrophy: Is the RAAS an important target?

Hatem Amer, Matthew D. Griffin

Research output: Contribution to journalComment/debate

7 Scopus citations


In follow-up to a recently published randomized controlled clinical trial, Issa et al. provide evidence that systemic activity and physiological responsiveness of the renin aldosterone angiotensin system (RAAS) are well within normal limits in most kidney recipients during the first 5 years post-transplant. Implications of the results include the need to better understand intra-renal RAAS activity in transplanted kidneys and to identify patients in which the graft-protective effects of RAAS blockade are most relevant.

Original languageEnglish (US)
Pages (from-to)240-243
Number of pages4
JournalKidney international
Issue number2
StatePublished - Feb 2014


ASJC Scopus subject areas

  • Nephrology

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