Modifying the Host Range Properties of Retroviral Vectors

Stephen J. Russell, François Loïc Cosset

Research output: Contribution to journalReview articlepeer-review

75 Scopus citations

Abstract

Gene therapy protocols would be greatly facilitated by the availability of targetable injectable vectors which could deliver genes in vivo to specific target cells or to specific disease sites. Efforts to develop such retroviral vectors are therefore a high priority in gene therapy research. In this review, we describe the current state of our understanding of the structure and function of the retroviral envelope glycoprotein complex. We then discuss the results of the various strategies that have been devised to modify the host range of the retroviral envelope glycoproteins with a view to achieving retroviral vectors capable of delivering their genes in a highly specific manner to selected human target cells. The strengths and limitations of these strategies are examined.

Original languageEnglish (US)
Pages (from-to)300-311
Number of pages12
JournalJournal of Gene Medicine
Volume1
Issue number5
DOIs
StatePublished - Jan 1 1999

Keywords

  • Envelope glycoproteins
  • Retroviral vector
  • Targeting

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Drug Discovery
  • Genetics(clinical)

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