Modified radical hysterectomy in the treatment of early squamous cervical cancer

Javier F. Magrina, Martha A. Goodrich, Thomas K. Lidner, Amy L. Weaver, Jeffrey L Cornella, Karl C. Podratz

Research output: Contribution to journalArticle

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Abstract

Objective. The aim of this study was to evaluate the results of modified radical hysterectomy in the treatment of early cervical cancer. Material and Methods. A retrospective chart review of 56 patients with stage I (IA in 35, IB in 21) squamous cervical carcinoma treated with modified radical hysterectomy and followed for a minimum of 5 years (mean, 12 years; range, 5.1-29) was conducted. All pathology slides were reviewed for tumor size, grade, depth of invasion, and lymph-vascular permeation. Results. The mean depth of invasion was 0.5 cm (range, 0.1-2.5 cm), and the mean tumor size was 1.1 cm (range, 0.1-7 cm). Only 3 patients (5.4%) had positive nodes. None of the patients with tumors 2 cm or less in size had positive nodes, whereas 33.3% of the patients with tumors more than 2 cm in size had positive nodes. A recurrence developed in 2 patients (5-year recurrence rate of 3.6%). There were 10 deaths during the entire follow-up period, but only 2 were related to cervical cancer. The disease-specific and overall 5-year survival rates were 96.4 and 94.6%, respectively. The disease-specific 5-year survival rate was 100% among the 47 patients with tumors 2 cm or less and 75% for the 9 patients with tumors larger than 2 cm. Univariate analysis identified stage, lymph node status, and tumor size as statistically significant prognostic factors for overall survival. Tumor grade, lymph-vascular permeation, and depth of invasion (1-3 mm vs >3 mm) were not statistically significant for overall survival. Conclusions. Modified radical hysterectomy appears to be effective surgical therapy for patients with squamous cervical carcinoma 2 cm or less in size.

Original languageEnglish (US)
Pages (from-to)183-186
Number of pages4
JournalGynecologic Oncology
Volume72
Issue number2
DOIs
StatePublished - Feb 1999

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Hysterectomy
Uterine Cervical Neoplasms
Neoplasms
Lymph
Therapeutics
Blood Vessels
Squamous Cell Carcinoma
Survival Rate
Recurrence
Survival
Lymph Nodes
Pathology

Keywords

  • Cervical cancer
  • Modified radical hysterectomy

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Magrina, J. F., Goodrich, M. A., Lidner, T. K., Weaver, A. L., Cornella, J. L., & Podratz, K. C. (1999). Modified radical hysterectomy in the treatment of early squamous cervical cancer. Gynecologic Oncology, 72(2), 183-186. https://doi.org/10.1006/gyno.1998.5245

Modified radical hysterectomy in the treatment of early squamous cervical cancer. / Magrina, Javier F.; Goodrich, Martha A.; Lidner, Thomas K.; Weaver, Amy L.; Cornella, Jeffrey L; Podratz, Karl C.

In: Gynecologic Oncology, Vol. 72, No. 2, 02.1999, p. 183-186.

Research output: Contribution to journalArticle

Magrina, JF, Goodrich, MA, Lidner, TK, Weaver, AL, Cornella, JL & Podratz, KC 1999, 'Modified radical hysterectomy in the treatment of early squamous cervical cancer', Gynecologic Oncology, vol. 72, no. 2, pp. 183-186. https://doi.org/10.1006/gyno.1998.5245
Magrina, Javier F. ; Goodrich, Martha A. ; Lidner, Thomas K. ; Weaver, Amy L. ; Cornella, Jeffrey L ; Podratz, Karl C. / Modified radical hysterectomy in the treatment of early squamous cervical cancer. In: Gynecologic Oncology. 1999 ; Vol. 72, No. 2. pp. 183-186.
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AU - Podratz, Karl C.

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N2 - Objective. The aim of this study was to evaluate the results of modified radical hysterectomy in the treatment of early cervical cancer. Material and Methods. A retrospective chart review of 56 patients with stage I (IA in 35, IB in 21) squamous cervical carcinoma treated with modified radical hysterectomy and followed for a minimum of 5 years (mean, 12 years; range, 5.1-29) was conducted. All pathology slides were reviewed for tumor size, grade, depth of invasion, and lymph-vascular permeation. Results. The mean depth of invasion was 0.5 cm (range, 0.1-2.5 cm), and the mean tumor size was 1.1 cm (range, 0.1-7 cm). Only 3 patients (5.4%) had positive nodes. None of the patients with tumors 2 cm or less in size had positive nodes, whereas 33.3% of the patients with tumors more than 2 cm in size had positive nodes. A recurrence developed in 2 patients (5-year recurrence rate of 3.6%). There were 10 deaths during the entire follow-up period, but only 2 were related to cervical cancer. The disease-specific and overall 5-year survival rates were 96.4 and 94.6%, respectively. The disease-specific 5-year survival rate was 100% among the 47 patients with tumors 2 cm or less and 75% for the 9 patients with tumors larger than 2 cm. Univariate analysis identified stage, lymph node status, and tumor size as statistically significant prognostic factors for overall survival. Tumor grade, lymph-vascular permeation, and depth of invasion (1-3 mm vs >3 mm) were not statistically significant for overall survival. Conclusions. Modified radical hysterectomy appears to be effective surgical therapy for patients with squamous cervical carcinoma 2 cm or less in size.

AB - Objective. The aim of this study was to evaluate the results of modified radical hysterectomy in the treatment of early cervical cancer. Material and Methods. A retrospective chart review of 56 patients with stage I (IA in 35, IB in 21) squamous cervical carcinoma treated with modified radical hysterectomy and followed for a minimum of 5 years (mean, 12 years; range, 5.1-29) was conducted. All pathology slides were reviewed for tumor size, grade, depth of invasion, and lymph-vascular permeation. Results. The mean depth of invasion was 0.5 cm (range, 0.1-2.5 cm), and the mean tumor size was 1.1 cm (range, 0.1-7 cm). Only 3 patients (5.4%) had positive nodes. None of the patients with tumors 2 cm or less in size had positive nodes, whereas 33.3% of the patients with tumors more than 2 cm in size had positive nodes. A recurrence developed in 2 patients (5-year recurrence rate of 3.6%). There were 10 deaths during the entire follow-up period, but only 2 were related to cervical cancer. The disease-specific and overall 5-year survival rates were 96.4 and 94.6%, respectively. The disease-specific 5-year survival rate was 100% among the 47 patients with tumors 2 cm or less and 75% for the 9 patients with tumors larger than 2 cm. Univariate analysis identified stage, lymph node status, and tumor size as statistically significant prognostic factors for overall survival. Tumor grade, lymph-vascular permeation, and depth of invasion (1-3 mm vs >3 mm) were not statistically significant for overall survival. Conclusions. Modified radical hysterectomy appears to be effective surgical therapy for patients with squamous cervical carcinoma 2 cm or less in size.

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