Modification of the lipidic and coagulative pattern in postmenopause women: Effect of hormone replacement therapy

G. Evola, G. Novo, G. Amoroso, D. Guttilla, L. Lo Coco, M. Guagliardo, A. Lupo, M. R. Averna, V. Giambanco, V. Miller, S. Novo

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Abstract

Aim. We evaluated the changes of lipidic and coagulative pattern during menopause and the influence of hormone replacement therapy (HRT) on these parameters. Methods. We considered 158 patients divided into 2 groups: Group I consisted of 127 women in physiological/surgical menopause and Group II of 31 women with childbearing potential. Subsequently, we considered a group III formed of 34 patients from menopausal women (group I) who underwent three months of HRT. We evaluated total-cholesterol (TC), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), triglycerides (TG), lipoprotein (a) (Lpa), fibrinogen, antithrombin III (ATIII), factor VII (FVII) and tissue factor pathway inhibitor (TFPI). Results. We found a worse lipid profile in the postmenopausal group compared to controls (TC 243.8±29.7 vs 217.9±32.7 mg%, P=0.002; TG 121.5±68.4 vs 88.6±53.0 mg%, P=0.039; LDL-C 163.0±27.9 vs 136.2±29.6 mg%, P=0.004; HDL-C 60.9±14.9 vs 64.1±14.6 mg%, P=ns). With regard to the coagulative pattern, fibrinogen was significantly higher in the post-menopausal group (fibrinogen: 273.3±67.4 vs 243.8±39.5 mg%, P=0.013; ATIII 112.2±11.7 vs 117.5±12.7% %, P=0.059; FVII 121.6*11.3 vs 117.6±10.8 mg%, P=ns; TFPI activity 2.5±2.3 vs 2.1±1.1 V/mL, P=ns; TFPI antigen 120±38 vs 127±39 U/mL, P=ns). Comparing the same parameters, before and after three months of HRT, in patients of Group III we observed a significant improvement of TC and TG levels (TC from 232.3±42.7 to 215.2±37.6 mg%, P=0.0001; TG from 103.7±56.8 to 95.0±44.3 mg%, P=0.059; HDL-C from 62.3±12.9 to 63.6±12.6 mg%, P=ns; LDL-C from 149.3±38.7 to 132.6±34.5 mg%, P=0.0001). The following changes were observed with regard to coagulative parameters: fibrinogen from 270.9±69.4 to 253.2±56.2 mg%, P=0.07; ATIII from 113.5±11.4 to 110.8±13.2 mg%, P=0.198; FVII from 108.6±18.0 to 104.4±17.5 mg%, 0.014. TFPI activity from 2.6*2.3 to 2.3*1.4 U/ml, P=ns; TFPI antigen from 68*13 to 87*22 U/mL, P=0.001. Conclusions. Our data confirm the presence of an alteration in lipidic and coagulative pattern in post menopausal women and positive changes after HRT.

Original languageEnglish (US)
Pages (from-to)355-361
Number of pages7
JournalInternational Angiology
Volume29
Issue number4
StatePublished - Aug 1 2010

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Keywords

  • Hormone replacement therapy
  • Menopause
  • Tissue factor pathway inhibitor

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Evola, G., Novo, G., Amoroso, G., Guttilla, D., Lo Coco, L., Guagliardo, M., Lupo, A., Averna, M. R., Giambanco, V., Miller, V., & Novo, S. (2010). Modification of the lipidic and coagulative pattern in postmenopause women: Effect of hormone replacement therapy. International Angiology, 29(4), 355-361.