Modest visceral fat gain causes endothelial dysfunction in healthy humans

Abel Romero-Corral, Fatima H. Sert-Kuniyoshi, Justo Sierra-Johnson, Marek Orban, Apoor Gami, Diane Davison, Prachi Singh, Snigdha Pusalavidyasagar, Christine Huyber, Susanne Votruba, Francisco Lopez-Jimenez, Michael Dennis Jensen, Virend Somers

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Objectives: The aim of this study was to determine the impact of fat gain and its distribution on endothelial function in lean healthy humans. Background: Endothelial dysfunction has been identified as an independent predictor of cardiovascular events. Whether fat gain impairs endothelial function is unknown. Methods: A randomized controlled study was conducted to assess the effects of fat gain on endothelial function. Forty-three normal-weight healthy volunteers were recruited (mean age 29 years; 18 women). Subjects were assigned to gain weight (approximately 4 kg) (n = 35) or to maintain weight (n = 8). Endothelial function (brachial artery flow-mediated dilation [FMD]) was measured at baseline, after fat gain (8 weeks), and after weight loss (16 weeks) for fat gainers and at baseline and follow-up (8 weeks) for weight maintainers. Body composition was measured by dual-energy X-ray absorptiometry and abdominal computed tomographic scans. Results: After an average weight gain of 4.1 kg, fat gainers significantly increased their total, visceral, and subcutaneous fat. Blood pressure and overnight polysomnography did not change after fat gain or loss. FMD remained unchanged in weight maintainers. FMD decreased in fat gainers (9.1 ± 3% vs. 7.8 ± 3.2%, p = 0.003) but recovered to baseline when subjects shed the gained weight. There was a significant correlation between the decrease in FMD and the increase in visceral fat gain (rho = -0.42, p = 0.004), but not with subcutaneous fat gain (rho = -0.22, p = 0.15). Conclusions: In normal-weight healthy young subjects, modest fat gain results in impaired endothelial function, even in the absence of changes in blood pressure. Endothelial function recovers after weight loss. Increased visceral rather than subcutaneous fat predicts endothelial dysfunction. (Fat Gain and Cardiovascular Disease Mechanisms; NCT00589498)

Original languageEnglish (US)
Pages (from-to)662-666
Number of pages5
JournalJournal of the American College of Cardiology
Volume56
Issue number8
DOIs
StatePublished - Aug 17 2010

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Intra-Abdominal Fat
Fats
Weights and Measures
Dilatation
Subcutaneous Fat
Weight Gain
Weight Loss
Healthy Volunteers
Blood Pressure
Brachial Artery
Polysomnography
Photon Absorptiometry
Body Composition
Cardiovascular Diseases

Keywords

  • BMI
  • body mass index
  • C-reactive protein
  • CRP
  • flow-mediated dilation
  • FMD

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Romero-Corral, A., Sert-Kuniyoshi, F. H., Sierra-Johnson, J., Orban, M., Gami, A., Davison, D., ... Somers, V. (2010). Modest visceral fat gain causes endothelial dysfunction in healthy humans. Journal of the American College of Cardiology, 56(8), 662-666. https://doi.org/10.1016/j.jacc.2010.03.063

Modest visceral fat gain causes endothelial dysfunction in healthy humans. / Romero-Corral, Abel; Sert-Kuniyoshi, Fatima H.; Sierra-Johnson, Justo; Orban, Marek; Gami, Apoor; Davison, Diane; Singh, Prachi; Pusalavidyasagar, Snigdha; Huyber, Christine; Votruba, Susanne; Lopez-Jimenez, Francisco; Jensen, Michael Dennis; Somers, Virend.

In: Journal of the American College of Cardiology, Vol. 56, No. 8, 17.08.2010, p. 662-666.

Research output: Contribution to journalArticle

Romero-Corral, A, Sert-Kuniyoshi, FH, Sierra-Johnson, J, Orban, M, Gami, A, Davison, D, Singh, P, Pusalavidyasagar, S, Huyber, C, Votruba, S, Lopez-Jimenez, F, Jensen, MD & Somers, V 2010, 'Modest visceral fat gain causes endothelial dysfunction in healthy humans', Journal of the American College of Cardiology, vol. 56, no. 8, pp. 662-666. https://doi.org/10.1016/j.jacc.2010.03.063
Romero-Corral A, Sert-Kuniyoshi FH, Sierra-Johnson J, Orban M, Gami A, Davison D et al. Modest visceral fat gain causes endothelial dysfunction in healthy humans. Journal of the American College of Cardiology. 2010 Aug 17;56(8):662-666. https://doi.org/10.1016/j.jacc.2010.03.063
Romero-Corral, Abel ; Sert-Kuniyoshi, Fatima H. ; Sierra-Johnson, Justo ; Orban, Marek ; Gami, Apoor ; Davison, Diane ; Singh, Prachi ; Pusalavidyasagar, Snigdha ; Huyber, Christine ; Votruba, Susanne ; Lopez-Jimenez, Francisco ; Jensen, Michael Dennis ; Somers, Virend. / Modest visceral fat gain causes endothelial dysfunction in healthy humans. In: Journal of the American College of Cardiology. 2010 ; Vol. 56, No. 8. pp. 662-666.
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AU - Davison, Diane

AU - Singh, Prachi

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AB - Objectives: The aim of this study was to determine the impact of fat gain and its distribution on endothelial function in lean healthy humans. Background: Endothelial dysfunction has been identified as an independent predictor of cardiovascular events. Whether fat gain impairs endothelial function is unknown. Methods: A randomized controlled study was conducted to assess the effects of fat gain on endothelial function. Forty-three normal-weight healthy volunteers were recruited (mean age 29 years; 18 women). Subjects were assigned to gain weight (approximately 4 kg) (n = 35) or to maintain weight (n = 8). Endothelial function (brachial artery flow-mediated dilation [FMD]) was measured at baseline, after fat gain (8 weeks), and after weight loss (16 weeks) for fat gainers and at baseline and follow-up (8 weeks) for weight maintainers. Body composition was measured by dual-energy X-ray absorptiometry and abdominal computed tomographic scans. Results: After an average weight gain of 4.1 kg, fat gainers significantly increased their total, visceral, and subcutaneous fat. Blood pressure and overnight polysomnography did not change after fat gain or loss. FMD remained unchanged in weight maintainers. FMD decreased in fat gainers (9.1 ± 3% vs. 7.8 ± 3.2%, p = 0.003) but recovered to baseline when subjects shed the gained weight. There was a significant correlation between the decrease in FMD and the increase in visceral fat gain (rho = -0.42, p = 0.004), but not with subcutaneous fat gain (rho = -0.22, p = 0.15). Conclusions: In normal-weight healthy young subjects, modest fat gain results in impaired endothelial function, even in the absence of changes in blood pressure. Endothelial function recovers after weight loss. Increased visceral rather than subcutaneous fat predicts endothelial dysfunction. (Fat Gain and Cardiovascular Disease Mechanisms; NCT00589498)

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