TY - JOUR
T1 - Modest alcohol consumption and risk of advanced liver fibrosis in nonalcoholic fatty liver disease
T2 - A systematic review and meta-analysis
AU - Wijarnpreecha, Karn
AU - Aby, Elizabeth S.
AU - Panjawatanan, Panadeekarn
AU - Lapumnuaypol, Kamolyut
AU - Cheungpasitporn, Wisit
AU - Lukens, Frank J.
AU - Harnois, Denise M.
AU - Ungprasert, Patompong
N1 - Publisher Copyright:
© 2021 Hellenic Society of Gastroenterology.
PY - 2021/7/16
Y1 - 2021/7/16
N2 - Background Recent studies have suggested an association between modest alcohol consumption and a decreased risk of advanced liver fibrosis among patients with nonalcoholic fatty liver disease (NAFLD) although the results are inconsistent. The current systematic review and meta-analysis was conducted to comprehensively investigate this possible association by identifying all the relevant studies and combining their results. Methods A comprehensive literature review was conducted utilizing the MEDLINE and EMBASE databases through February 2019 to identify all cross-sectional studies that compared the prevalence of advanced liver fibrosis among NAFLD patients who were modest alcohol drinkers to NAFLD patients who were non-drinkers. Effect estimates from each study were extracted and combined together using the random-effect, generic inverse variance method of DerSimonian and Laird. Results A total of 6 studies with 8,936 participants fulfilled the eligibility criteria and were included in the meta-analysis. The risk of advanced liver fibrosis among patients with NAFLD who were modest alcohol drinkers was significantly lower compared to patients with NAFLD who were non-drinkers with a pooled odds ratio of 0.51 (95% confidence interval [CI] 0.35-0.75; I2 47%). The funnel plot was symmetric and was not suggestive of publication bias. Conclusion A significantly lower risk of advanced liver fibrosis was observed among NAFLD patients who were modest alcohol drinkers compared to non-drinkers in this meta-analysis.
AB - Background Recent studies have suggested an association between modest alcohol consumption and a decreased risk of advanced liver fibrosis among patients with nonalcoholic fatty liver disease (NAFLD) although the results are inconsistent. The current systematic review and meta-analysis was conducted to comprehensively investigate this possible association by identifying all the relevant studies and combining their results. Methods A comprehensive literature review was conducted utilizing the MEDLINE and EMBASE databases through February 2019 to identify all cross-sectional studies that compared the prevalence of advanced liver fibrosis among NAFLD patients who were modest alcohol drinkers to NAFLD patients who were non-drinkers. Effect estimates from each study were extracted and combined together using the random-effect, generic inverse variance method of DerSimonian and Laird. Results A total of 6 studies with 8,936 participants fulfilled the eligibility criteria and were included in the meta-analysis. The risk of advanced liver fibrosis among patients with NAFLD who were modest alcohol drinkers was significantly lower compared to patients with NAFLD who were non-drinkers with a pooled odds ratio of 0.51 (95% confidence interval [CI] 0.35-0.75; I2 47%). The funnel plot was symmetric and was not suggestive of publication bias. Conclusion A significantly lower risk of advanced liver fibrosis was observed among NAFLD patients who were modest alcohol drinkers compared to non-drinkers in this meta-analysis.
KW - Alcohol
KW - Hepatic steatosis
KW - Liver fibrosis
KW - Meta-analysis
KW - Nonalcoholic steatohepatitis
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U2 - 10.20524/aog.2021.0612
DO - 10.20524/aog.2021.0612
M3 - Article
AN - SCOPUS:85112077920
SN - 1108-7471
VL - 34
SP - 568
EP - 574
JO - Annals of Gastroenterology
JF - Annals of Gastroenterology
IS - 4
ER -