Modest agreement between magnetic resonance and pathological tumor regression after neoadjuvant therapy for rectal cancer in the real world

Pietro Achilli, Carmelo Magistro, Mohamed A. Abd El Aziz, Giacomo Calini, Camillo L. Bertoglio, Giovanni Ferrari, Giulio Mari, Dario Maggioni, Georgios Peros, Sara Tamburello, Elisabetta Coppola, Antonino Spinelli, Fabian Grass, David Martin, Dieter Hahnloser, Andrea Salvatori, Silvia De Simoni, Shannon Sheedy, Joel G. Fletcher, David W. Larson

Research output: Contribution to journalArticlepeer-review

Abstract

Magnetic resonance imaging (MRI) is routinely used for preoperative tumor staging and to assess response to therapy in rectal cancer patients. The aim of our study was to evaluate the accuracy of MRI based restaging after neoadjuvant chemoradiotherapy (CRT) in predicting pathologic response. This multicenter cohort study included adult patients with histologically confirmed locally advanced rectal adenocarcinoma treated with neoadjuvant CRT followed by curative intent elective surgery between January 2014 and December 2019 at four academic high-volume institutions. Magnetic resonance tumor regression grade (mrTRG) and pathologic tumor regression grade (pTRG) were reviewed and compared for all the patients. The agreement between radiologist and pathologist was assessed with the weighted k test. Risk factors for poor agreement were investigated using logistic regression. A total of 309 patients were included. Modest agreement was found between mrTRG and pTRG when regression was classified according to standard five-tier systems (k = 0.386). When only two categories were considered for each regression system, (pTRG 0-3 vs pTRG 4; mrTRG 2-5 vs mrTRG 1) an accuracy of 78% (95% confidence interval [CI] 0.73-0.83) was found between radiologic and pathologic assessment with a k value of 0.185. The logistic regression model revealed that “T3 greater than 5 mm extent” was the only variable significantly impacting on disagreement (OR 0.33, 95% CI 0.15-0.68, P =.0034). Modest agreement exists between mrTRG and pTRG. The chances of appropriate assessment of the regression grade after neoadjuvant CRT appear to be higher in case of a T3 tumor with at least 5 mm extension in the mesorectal fat at the pretreatment MRI.

Original languageEnglish (US)
JournalInternational Journal of Cancer
DOIs
StateAccepted/In press - 2022

Keywords

  • agreement analysis
  • magnetic resonance
  • neoadjuvant therapy
  • rectal cancer
  • tumor regression grade

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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