Modern management of prosthetic valve anticoagulation

Daniel J. Tiede, Rick A. Nishimura, Dennis A. Gastineau, Charles J. Mullany, Thomas A. Orszulak, Hartzell V Schaff

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Prosthetic heart valves have been effectively used for many years. Nonetheless, they are associated with risks of thrombosis and thromboembolic events, as well as anti. coagulation-induced bleeding. Substantial changes in anticoagulation measurement and dosing have occurred during the past several years. In this review, the rationale for anticoagulation in patients with prosthetic heart valves, the changes in monitoring and dosing, and the comparison of relevant anticoagulation trials are discussed. On the basis of the existing data, new recommendations regarding lower anticoagulation levels are offered, utilizing a single value goal rather than the traditional therapeutic range. Perioperative management of anticoagulation is discussed in light of the available literature, and major drug interactions are reviewed.

Original languageEnglish (US)
Pages (from-to)665-680
Number of pages16
JournalMayo Clinic Proceedings
Volume73
Issue number7
StatePublished - 1998

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Heart Valves
Drug Interactions
Thrombosis
Hemorrhage
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tiede, D. J., Nishimura, R. A., Gastineau, D. A., Mullany, C. J., Orszulak, T. A., & Schaff, H. V. (1998). Modern management of prosthetic valve anticoagulation. Mayo Clinic Proceedings, 73(7), 665-680.

Modern management of prosthetic valve anticoagulation. / Tiede, Daniel J.; Nishimura, Rick A.; Gastineau, Dennis A.; Mullany, Charles J.; Orszulak, Thomas A.; Schaff, Hartzell V.

In: Mayo Clinic Proceedings, Vol. 73, No. 7, 1998, p. 665-680.

Research output: Contribution to journalArticle

Tiede, DJ, Nishimura, RA, Gastineau, DA, Mullany, CJ, Orszulak, TA & Schaff, HV 1998, 'Modern management of prosthetic valve anticoagulation', Mayo Clinic Proceedings, vol. 73, no. 7, pp. 665-680.
Tiede DJ, Nishimura RA, Gastineau DA, Mullany CJ, Orszulak TA, Schaff HV. Modern management of prosthetic valve anticoagulation. Mayo Clinic Proceedings. 1998;73(7):665-680.
Tiede, Daniel J. ; Nishimura, Rick A. ; Gastineau, Dennis A. ; Mullany, Charles J. ; Orszulak, Thomas A. ; Schaff, Hartzell V. / Modern management of prosthetic valve anticoagulation. In: Mayo Clinic Proceedings. 1998 ; Vol. 73, No. 7. pp. 665-680.
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