Abstract
Currently, animal models are available that closely resemble human myocarditis. Coxsackievirus B3 (CVB3)-induced myocarditis models fall into two major categories: direct viral damage models and virus-triggered autoimmune models. Debate focuses on whether CVB3 can cause autoimmune heart disease or whether myocardial inflammation is due to direct damage or persistence of virus. Recent findings strengthen the argument that CVB3 triggers autoimmune myocarditis in mice without the requirement for active viral replication.
Original language | English (US) |
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Pages (from-to) | 381-386 |
Number of pages | 6 |
Journal | Drug Discovery Today: Disease Models |
Volume | 1 |
Issue number | 4 |
DOIs | |
State | Published - Dec 2004 |
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery