Modeling of cancer virotherapy with recombinant measles viruses

Željko Bajzer, Thomas Carr, Krešimir Josić, Stephen J Russell, David M Dingli

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

The Edmonston vaccine strain of measles virus has potent and selective activity against a wide range of tumors. Tumor cells infected by this virus or genetically modified strains express viral proteins that allow them to fuse with neighboring cells to form syncytia that ultimately die. Moreover, infected cells may produce new virus particles that proceed to infect additional tumor cells. We present a model of tumor and virus interactions based on established biology and with proper accounting of the free virus population. The range of model parameters is estimated by fitting to available experimental data. The stability of equilibrium states corresponding to complete tumor eradication, therapy failure and partial tumor reduction is discussed. We use numerical simulations to explore conditions for which the model predicts successful therapy and tumor eradication. The model exhibits damped, as well as stable oscillations in a range of parameter values. These oscillatory states are organized by a Hopf bifurcation.

Original languageEnglish (US)
Pages (from-to)109-122
Number of pages14
JournalJournal of Theoretical Biology
Volume252
Issue number1
DOIs
StatePublished - May 7 2008

Fingerprint

Measles virus
Viruses
Virus
Tumors
Tumor
Cancer
neoplasms
Modeling
Neoplasms
viruses
Cell
Therapy
therapeutics
viral proteins
giant cells
Cells
Oncogenic Viruses
Range of data
virion
Viral Proteins

Keywords

  • Cancer therapy
  • Oscillatory dynamical systems
  • Population dynamics
  • Tumor growth modeling

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Modeling of cancer virotherapy with recombinant measles viruses. / Bajzer, Željko; Carr, Thomas; Josić, Krešimir; Russell, Stephen J; Dingli, David M.

In: Journal of Theoretical Biology, Vol. 252, No. 1, 07.05.2008, p. 109-122.

Research output: Contribution to journalArticle

Bajzer, Željko ; Carr, Thomas ; Josić, Krešimir ; Russell, Stephen J ; Dingli, David M. / Modeling of cancer virotherapy with recombinant measles viruses. In: Journal of Theoretical Biology. 2008 ; Vol. 252, No. 1. pp. 109-122.
@article{12331a5cb8e94512b6c58ca8d7c6b93d,
title = "Modeling of cancer virotherapy with recombinant measles viruses",
abstract = "The Edmonston vaccine strain of measles virus has potent and selective activity against a wide range of tumors. Tumor cells infected by this virus or genetically modified strains express viral proteins that allow them to fuse with neighboring cells to form syncytia that ultimately die. Moreover, infected cells may produce new virus particles that proceed to infect additional tumor cells. We present a model of tumor and virus interactions based on established biology and with proper accounting of the free virus population. The range of model parameters is estimated by fitting to available experimental data. The stability of equilibrium states corresponding to complete tumor eradication, therapy failure and partial tumor reduction is discussed. We use numerical simulations to explore conditions for which the model predicts successful therapy and tumor eradication. The model exhibits damped, as well as stable oscillations in a range of parameter values. These oscillatory states are organized by a Hopf bifurcation.",
keywords = "Cancer therapy, Oscillatory dynamical systems, Population dynamics, Tumor growth modeling",
author = "Željko Bajzer and Thomas Carr and Krešimir Josić and Russell, {Stephen J} and Dingli, {David M}",
year = "2008",
month = "5",
day = "7",
doi = "10.1016/j.jtbi.2008.01.016",
language = "English (US)",
volume = "252",
pages = "109--122",
journal = "Journal of Theoretical Biology",
issn = "0022-5193",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Modeling of cancer virotherapy with recombinant measles viruses

AU - Bajzer, Željko

AU - Carr, Thomas

AU - Josić, Krešimir

AU - Russell, Stephen J

AU - Dingli, David M

PY - 2008/5/7

Y1 - 2008/5/7

N2 - The Edmonston vaccine strain of measles virus has potent and selective activity against a wide range of tumors. Tumor cells infected by this virus or genetically modified strains express viral proteins that allow them to fuse with neighboring cells to form syncytia that ultimately die. Moreover, infected cells may produce new virus particles that proceed to infect additional tumor cells. We present a model of tumor and virus interactions based on established biology and with proper accounting of the free virus population. The range of model parameters is estimated by fitting to available experimental data. The stability of equilibrium states corresponding to complete tumor eradication, therapy failure and partial tumor reduction is discussed. We use numerical simulations to explore conditions for which the model predicts successful therapy and tumor eradication. The model exhibits damped, as well as stable oscillations in a range of parameter values. These oscillatory states are organized by a Hopf bifurcation.

AB - The Edmonston vaccine strain of measles virus has potent and selective activity against a wide range of tumors. Tumor cells infected by this virus or genetically modified strains express viral proteins that allow them to fuse with neighboring cells to form syncytia that ultimately die. Moreover, infected cells may produce new virus particles that proceed to infect additional tumor cells. We present a model of tumor and virus interactions based on established biology and with proper accounting of the free virus population. The range of model parameters is estimated by fitting to available experimental data. The stability of equilibrium states corresponding to complete tumor eradication, therapy failure and partial tumor reduction is discussed. We use numerical simulations to explore conditions for which the model predicts successful therapy and tumor eradication. The model exhibits damped, as well as stable oscillations in a range of parameter values. These oscillatory states are organized by a Hopf bifurcation.

KW - Cancer therapy

KW - Oscillatory dynamical systems

KW - Population dynamics

KW - Tumor growth modeling

UR - http://www.scopus.com/inward/record.url?scp=41949097523&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=41949097523&partnerID=8YFLogxK

U2 - 10.1016/j.jtbi.2008.01.016

DO - 10.1016/j.jtbi.2008.01.016

M3 - Article

C2 - 18316099

AN - SCOPUS:41949097523

VL - 252

SP - 109

EP - 122

JO - Journal of Theoretical Biology

JF - Journal of Theoretical Biology

SN - 0022-5193

IS - 1

ER -