Modeling nerve conduction criteria for diagnosis of diabetic polyneuropathy

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Abstract

Introduction: In this study we aimed to determine which criteria are valid for nerve conduction (NC) diagnosis of typical diabetic sensorimotor polyneuropathy (DSPN). Methods: Eight criteria were assessed from among diabetes databases, the Rochester Diabetic Neuropathy Study (RDNS, N = 456), and in healthy subjects (RDNS-HS, N = 330). Results: In the RDNS, the most frequent abnormal attributes (≤2.5th/≥97.5th percentile) are: fibular motor nerve conduction velocity (MNCV; 26.3%); sural sensory nerve conduction velocity (SNAP; 25.4%); tibial MNCV (24.8%); ulnar MNCV (21.3%); fibular F latency (16.9%); and ulnar F latency (16.0%). Normal deviate (from percentiles) composite scores of NC included: representative of neurophysiological abnormalities; sensitive and specific for diagnosis and useful for epidemiological surveys; randomized trials; and medical practice. By contrast, abnormality of one or more attributes in any nerve or abnormally of two most sensitive attributes performed poorly. Conclusions: Composite sum scores of normal deviates (from percentiles corrected for applicable variables) of sensitive NC attributes and with modifications, RDNS and AAN criteria performed acceptably for diagnosis of DSPN.

Original languageEnglish (US)
Pages (from-to)340-345
Number of pages6
JournalMuscle and Nerve
Volume44
Issue number3
DOIs
StatePublished - Sep 1 2011

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Keywords

  • Composite scores of nerve conduction
  • Diabetic sensorimotor polyneuropathy
  • Diagnostic criteria
  • Nerve conduction
  • Sensitivity
  • Specificity of nerve test

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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