Modeling megakaryocyte development as a branching process

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Abstract

We have developed a computational method for directly fitting a stochastic branching model to colony growth data, which was then used to model development of colonies from human megakaryocytic stem cells. The overall fit is as good as indirect methods, such as the frequently used gamma function, but with far more interpretable parameters. The method is easily extended to more complex systems.

Original languageEnglish (US)
Pages (from-to)959-964
Number of pages6
JournalComputers and Mathematics with Applications
Volume18
Issue number10-11
DOIs
StatePublished - 1989

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ASJC Scopus subject areas

  • Modeling and Simulation
  • Computational Theory and Mathematics
  • Computational Mathematics

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