We have developed a computational method for directly fitting a stochastic branching model to colony growth data, which was then used to model development of colonies from human megakaryocytic stem cells. The overall fit is as good as indirect methods, such as the frequently used gamma function, but with far more interpretable parameters. The method is easily extended to more complex systems.
ASJC Scopus subject areas
- Modeling and Simulation
- Computational Theory and Mathematics
- Computational Mathematics