TY - JOUR
T1 - Modeling, analysis and optimization of calibration uncertainty in clinical laboratories
AU - Ramamohan, Varun
AU - Abbott, James T.
AU - Klee, George G.
AU - Yih, Yuehwern
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2014/4
Y1 - 2014/4
N2 - Uncertainty in the calibration of a clinical laboratory measurement process has a significant effect on the uncertainty of the measurement result. We develop a mathematical model of the analytical stage of the measurement of serum triglyceride concentration in the clinical laboratory, and use the Monte Carlo method to estimate the net uncertainty associated with this model. We then use the model to study the effect of instrument calibration on the uncertainty of the laboratory measurement result. The effect of the correlation between the parameters of the linear calibration function on the measurement result is quantified using the model. In addition, the effect of the choice of calibrator concentration levels on the measurement result distribution is studied using the model, by studying the effect of the value or the position of the calibrator concentration, and the difference or the distance between calibrator concentrations, on the uncertainty of the measurement result.
AB - Uncertainty in the calibration of a clinical laboratory measurement process has a significant effect on the uncertainty of the measurement result. We develop a mathematical model of the analytical stage of the measurement of serum triglyceride concentration in the clinical laboratory, and use the Monte Carlo method to estimate the net uncertainty associated with this model. We then use the model to study the effect of instrument calibration on the uncertainty of the laboratory measurement result. The effect of the correlation between the parameters of the linear calibration function on the measurement result is quantified using the model. In addition, the effect of the choice of calibrator concentration levels on the measurement result distribution is studied using the model, by studying the effect of the value or the position of the calibrator concentration, and the difference or the distance between calibrator concentrations, on the uncertainty of the measurement result.
KW - Calibration correlation analysis
KW - Clinical laboratory measurements
KW - Optimal calibrator selection
KW - Serum triglycerides
UR - http://www.scopus.com/inward/record.url?scp=84893124056&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893124056&partnerID=8YFLogxK
U2 - 10.1016/j.measurement.2013.12.027
DO - 10.1016/j.measurement.2013.12.027
M3 - Article
AN - SCOPUS:84893124056
SN - 0263-2241
VL - 50
SP - 175
EP - 185
JO - Measurement: Journal of the International Measurement Confederation
JF - Measurement: Journal of the International Measurement Confederation
IS - 1
ER -