Model for avulsion injury in the rat brachial plexus using passive acceleration

R. J. Spinner; A. Khoobehi; S. Kazmi; J. A. Krumreich; S. Zhao; Z. Zhang; D. G. Kline; R. W. Beuerman

doi:10.1002/(SICI)1098-2752(2000)20:2<94::AID-MICR8>3.0.CO;2-L

Model for avulsion injury in the rat brachial plexus using passive acceleration

R. J. Spinner, A. Khoobehi, S. Kazmi, J. A. Krumreich, S. Zhao, Z. Zhang, D. G. Kline, R. W. Beuerman

Neurosurgery

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We have developed an experimental model for brachial plexus injuries in the rat that closely simulates the characteristics of human injury. This model produces avulsion injuries in a noninvasive manner. A prototype apparatus was designed that allowed a force to be transmitted to a restrained limb by passive acceleration. Reproducible results were obtained in 32 rats. A significant correlation was found between the test weight and the number of roots avulsed (r = 0.92; P < 0.05). The amount of force also correlated to the pattern of avulsion injury: a 230-g weight produced either C6 (54%), C7 (15%), or C6 and C7 (31%) avulsions; a 330-g weight produced C6 (18%), C7 (9%), or C6 and C7 (73%) avulsions; a 530-g weight produced C5 through C8 (75%) or C6 through T1 (25%) avulsions. This model of brachial plexus injury may be useful to further our understanding of the cellular response to this incapacitating injury and to develop therapeutic strategies with behavioral correlates. (C) 2000 Wiley-Liss, Inc.

Original language	English (US)
Pages (from-to)	94-97
Number of pages	4
Journal	Microsurgery
Volume	20
Issue number	2
DOIs	https://doi.org/10.1002/(SICI)1098-2752(2000)20:2<94::AID-MICR8>3.0.CO;2-L
State	Published - 2000

ASJC Scopus subject areas

Surgery

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10.1002/(SICI)1098-2752(2000)20:2<94::AID-MICR8>3.0.CO;2-L

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title = "Model for avulsion injury in the rat brachial plexus using passive acceleration",

abstract = "We have developed an experimental model for brachial plexus injuries in the rat that closely simulates the characteristics of human injury. This model produces avulsion injuries in a noninvasive manner. A prototype apparatus was designed that allowed a force to be transmitted to a restrained limb by passive acceleration. Reproducible results were obtained in 32 rats. A significant correlation was found between the test weight and the number of roots avulsed (r = 0.92; P < 0.05). The amount of force also correlated to the pattern of avulsion injury: a 230-g weight produced either C6 (54%), C7 (15%), or C6 and C7 (31%) avulsions; a 330-g weight produced C6 (18%), C7 (9%), or C6 and C7 (73%) avulsions; a 530-g weight produced C5 through C8 (75%) or C6 through T1 (25%) avulsions. This model of brachial plexus injury may be useful to further our understanding of the cellular response to this incapacitating injury and to develop therapeutic strategies with behavioral correlates. (C) 2000 Wiley-Liss, Inc.",

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AU - Spinner, R. J.

AU - Khoobehi, A.

AU - Kazmi, S.

AU - Krumreich, J. A.

AU - Zhao, S.

AU - Zhang, Z.

AU - Kline, D. G.

AU - Beuerman, R. W.

PY - 2000

Y1 - 2000

N2 - We have developed an experimental model for brachial plexus injuries in the rat that closely simulates the characteristics of human injury. This model produces avulsion injuries in a noninvasive manner. A prototype apparatus was designed that allowed a force to be transmitted to a restrained limb by passive acceleration. Reproducible results were obtained in 32 rats. A significant correlation was found between the test weight and the number of roots avulsed (r = 0.92; P < 0.05). The amount of force also correlated to the pattern of avulsion injury: a 230-g weight produced either C6 (54%), C7 (15%), or C6 and C7 (31%) avulsions; a 330-g weight produced C6 (18%), C7 (9%), or C6 and C7 (73%) avulsions; a 530-g weight produced C5 through C8 (75%) or C6 through T1 (25%) avulsions. This model of brachial plexus injury may be useful to further our understanding of the cellular response to this incapacitating injury and to develop therapeutic strategies with behavioral correlates. (C) 2000 Wiley-Liss, Inc.

AB - We have developed an experimental model for brachial plexus injuries in the rat that closely simulates the characteristics of human injury. This model produces avulsion injuries in a noninvasive manner. A prototype apparatus was designed that allowed a force to be transmitted to a restrained limb by passive acceleration. Reproducible results were obtained in 32 rats. A significant correlation was found between the test weight and the number of roots avulsed (r = 0.92; P < 0.05). The amount of force also correlated to the pattern of avulsion injury: a 230-g weight produced either C6 (54%), C7 (15%), or C6 and C7 (31%) avulsions; a 330-g weight produced C6 (18%), C7 (9%), or C6 and C7 (73%) avulsions; a 530-g weight produced C5 through C8 (75%) or C6 through T1 (25%) avulsions. This model of brachial plexus injury may be useful to further our understanding of the cellular response to this incapacitating injury and to develop therapeutic strategies with behavioral correlates. (C) 2000 Wiley-Liss, Inc.

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Model for avulsion injury in the rat brachial plexus using passive acceleration

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