Model-Based Evaluation of Growth Hormone Secretion

Johannes D. Veldhuis, Daniel M. Keenan

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations

Abstract

A minimal-model framework is that growth hormone (GH) secretion is controlled by an ensemble of interlinked peptides, namely, GH-releasing hormone (GHRH), somatostatin (SS), and ghrelin. Clinical studies, laboratory experiments, rare sporadic mutations, targeted gene silencing, and biomathematical models establish that at least three signals regulate GH secretion. A clarion implication of the concept of integrative control is that no one peptidic effector operates alone or can be adequately studied alone. A major unanswered question is how pathophysiology disrupts the core regulatory ensemble, thereby forcing relative GH and IGF-1 deficiency or excess. However, salient technical hurdles exist, namely, the lack of reliable experimental strategies and the paucity of validated analytical tools to distinguish the interlinked roles of GHRH, SS, and ghrelin. To address these significant obstacles requires administering peptide secretagogues in distinct combinations akin to the classical insulin/glucose clamp and implementing an analytical formalism to parse the interactive roles of GHRH, SS, and ghrelin objectively.

Original languageEnglish (US)
Title of host publicationMethods in Enzymology
PublisherAcademic Press Inc
Pages231-248
Number of pages18
DOIs
StatePublished - Jan 2012

Publication series

NameMethods in Enzymology
Volume514
ISSN (Print)0076-6879
ISSN (Electronic)1557-7988

Keywords

  • GHS
  • feedback
  • ghrelin
  • growth hormone
  • pulsatile
  • secretagogue
  • secretion

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Fingerprint Dive into the research topics of 'Model-Based Evaluation of Growth Hormone Secretion'. Together they form a unique fingerprint.

Cite this