Modal subcomponents of metabolic syndrome in patients with bipolar disorder

Jeffrey Cardenas, Mark A Frye, Susan L. Marusak, Eric M. Levander, Jason W. Chirichigno, Stryder Lewis, Shoshanna Nakelsky, Sun Hwang, Jim Mintz, Lori L. Altshuler

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Background: The metabolic syndrome is a growing global public health problem. Objective: To evaluate the prevalence rate and modal subcomponents of the metabolic syndrome in subjects treated at the West Los Angeles Veterans Administration Medical Center Bipolar Clinic. Methods: In this cross-sectional design study, using the National Cholesterol Education Program definition, metabolic syndrome prevalence rates were calculated. Results: 48/98 (49%) of subjects met criteria for metabolic syndrome. There was no difference in prevalence rate by gender or race. Almost 70% of the cohort met criteria for metabolic syndrome by the components of reduced HDL and increased waist circumference. Treatment with carbamazepine at study entry was associated with a lower prevalence rate of metabolic syndrome. Limitations and conclusions: This study is limited by its small size and non-structured assessment of Axis I diagnosis. Nonetheless, bipolar patients in this select cohort have high rates of metabolic syndrome; given this cardiovascular risk, close clinical monitoring for these parameters is recommended. While not controlling for genetics, environmental influences, and/or medical factors such as additional comorbidity and treatment duration, psychotropic drug use may confer differential risk for developing the metabolic syndrome.

Original languageEnglish (US)
Pages (from-to)91-97
Number of pages7
JournalJournal of Affective Disorders
Volume106
Issue number1-2
DOIs
StatePublished - Feb 2008

Fingerprint

Bipolar Disorder
United States Department of Veterans Affairs
Los Angeles
Psychotropic Drugs
Carbamazepine
Waist Circumference
Comorbidity
Public Health
Cross-Sectional Studies
Cholesterol
Education
Therapeutics

Keywords

  • Bipolar disorder
  • Metabolic syndrome
  • Psychotropic

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

Cardenas, J., Frye, M. A., Marusak, S. L., Levander, E. M., Chirichigno, J. W., Lewis, S., ... Altshuler, L. L. (2008). Modal subcomponents of metabolic syndrome in patients with bipolar disorder. Journal of Affective Disorders, 106(1-2), 91-97. https://doi.org/10.1016/j.jad.2007.05.030

Modal subcomponents of metabolic syndrome in patients with bipolar disorder. / Cardenas, Jeffrey; Frye, Mark A; Marusak, Susan L.; Levander, Eric M.; Chirichigno, Jason W.; Lewis, Stryder; Nakelsky, Shoshanna; Hwang, Sun; Mintz, Jim; Altshuler, Lori L.

In: Journal of Affective Disorders, Vol. 106, No. 1-2, 02.2008, p. 91-97.

Research output: Contribution to journalArticle

Cardenas, J, Frye, MA, Marusak, SL, Levander, EM, Chirichigno, JW, Lewis, S, Nakelsky, S, Hwang, S, Mintz, J & Altshuler, LL 2008, 'Modal subcomponents of metabolic syndrome in patients with bipolar disorder', Journal of Affective Disorders, vol. 106, no. 1-2, pp. 91-97. https://doi.org/10.1016/j.jad.2007.05.030
Cardenas, Jeffrey ; Frye, Mark A ; Marusak, Susan L. ; Levander, Eric M. ; Chirichigno, Jason W. ; Lewis, Stryder ; Nakelsky, Shoshanna ; Hwang, Sun ; Mintz, Jim ; Altshuler, Lori L. / Modal subcomponents of metabolic syndrome in patients with bipolar disorder. In: Journal of Affective Disorders. 2008 ; Vol. 106, No. 1-2. pp. 91-97.
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