TY - JOUR
T1 - Mobile Microrobots for Active Therapeutic Delivery
AU - Erkoc, Pelin
AU - Yasa, Immihan C.
AU - Ceylan, Hakan
AU - Yasa, Oncay
AU - Alapan, Yunus
AU - Sitti, Metin
N1 - Funding Information:
P.E. and I.C.Y. contributed equally to this work. The authors acknowledge the Max Planck Society for funding.
Publisher Copyright:
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2019/1
Y1 - 2019/1
N2 - Recent advances in the versatility and sophistication of design, fabrication, and control methods of mobile microrobots could have a transforming impact on future healthcare technologies. Self-propelled or remotely actuated, synthetic, or biohybrid microrobots can navigate to difficult-to-reach regions in the human body to deliver therapeutics for microscopically localized medical interventions. Here, recent progress in the design of microrobotic systems concerning therapeutic delivery of drugs, cells, and genetic materials is reported. This perspective prioritizes the design aspects of microrobots for medical cargo loading, navigation in biologically relevant environments, and controlled cargo release. In the final section, future prospects and a discussion on the critical shortcomings for the benchside-to-bedside translation of medical microrobots are provided.
AB - Recent advances in the versatility and sophistication of design, fabrication, and control methods of mobile microrobots could have a transforming impact on future healthcare technologies. Self-propelled or remotely actuated, synthetic, or biohybrid microrobots can navigate to difficult-to-reach regions in the human body to deliver therapeutics for microscopically localized medical interventions. Here, recent progress in the design of microrobotic systems concerning therapeutic delivery of drugs, cells, and genetic materials is reported. This perspective prioritizes the design aspects of microrobots for medical cargo loading, navigation in biologically relevant environments, and controlled cargo release. In the final section, future prospects and a discussion on the critical shortcomings for the benchside-to-bedside translation of medical microrobots are provided.
KW - active therapeutic delivery
KW - cell-mediated delivery
KW - drug delivery
KW - microrobot
KW - single cell manipulation
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U2 - 10.1002/adtp.201800064
DO - 10.1002/adtp.201800064
M3 - Article
AN - SCOPUS:85101856916
SN - 2366-3987
VL - 2
JO - Advanced Therapeutics
JF - Advanced Therapeutics
IS - 1
M1 - 1800064
ER -