Mixed meal simulation model of glucose-insulin system

Chiara Dalla Man, Robert A. Rizza, Claudio Cobelli

Research output: Chapter in Book/Report/Conference proceedingConference contribution

23 Citations (Scopus)

Abstract

A simulation model of the glucose-insulin system in the postprandial state can be useful for studying the pathophysiology of diabetes. Here we present a new simulation model which describes the physiological events which occur after a meal, by employing the quantitative knowledge which has become available in recent years. Model parameters were set to fit data of 204 normal subjects which underwent a triple tracer meal protocol which provided quasi model-independent estimates of major glucose and insulin fluxes. Model results are shown in describing normal daily life (breakfast, lunch, dinner) both in normal and pathophysiological situations. The potential of the model for studying type 1 diabetes is illustrated by simulating both open- and closed-loop insulin infusion strategies.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Pages307-310
Number of pages4
DOIs
StatePublished - 2006
Event28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06 - New York, NY, United States
Duration: Aug 30 2006Sep 3 2006

Other

Other28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
CountryUnited States
CityNew York, NY
Period8/30/069/3/06

Fingerprint

Insulin
Glucose
Medical problems
Fluxes

ASJC Scopus subject areas

  • Bioengineering

Cite this

Dalla Man, C., Rizza, R. A., & Cobelli, C. (2006). Mixed meal simulation model of glucose-insulin system. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (pp. 307-310). [4029886] https://doi.org/10.1109/IEMBS.2006.260810

Mixed meal simulation model of glucose-insulin system. / Dalla Man, Chiara; Rizza, Robert A.; Cobelli, Claudio.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2006. p. 307-310 4029886.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Dalla Man, C, Rizza, RA & Cobelli, C 2006, Mixed meal simulation model of glucose-insulin system. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings., 4029886, pp. 307-310, 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06, New York, NY, United States, 8/30/06. https://doi.org/10.1109/IEMBS.2006.260810
Dalla Man C, Rizza RA, Cobelli C. Mixed meal simulation model of glucose-insulin system. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2006. p. 307-310. 4029886 https://doi.org/10.1109/IEMBS.2006.260810
Dalla Man, Chiara ; Rizza, Robert A. ; Cobelli, Claudio. / Mixed meal simulation model of glucose-insulin system. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2006. pp. 307-310
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