TY - GEN
T1 - Mixed meal simulation model of glucose-insulin system
AU - Dalla Man, Chiara
AU - Rizza, Robert A.
AU - Cobelli, Claudio
PY - 2006
Y1 - 2006
N2 - A simulation model of the glucose-insulin system in the postprandial state can be useful for studying the pathophysiology of diabetes. Here we present a new simulation model which describes the physiological events which occur after a meal, by employing the quantitative knowledge which has become available in recent years. Model parameters were set to fit data of 204 normal subjects which underwent a triple tracer meal protocol which provided quasi model-independent estimates of major glucose and insulin fluxes. Model results are shown in describing normal daily life (breakfast, lunch, dinner) both in normal and pathophysiological situations. The potential of the model for studying type 1 diabetes is illustrated by simulating both open- and closed-loop insulin infusion strategies.
AB - A simulation model of the glucose-insulin system in the postprandial state can be useful for studying the pathophysiology of diabetes. Here we present a new simulation model which describes the physiological events which occur after a meal, by employing the quantitative knowledge which has become available in recent years. Model parameters were set to fit data of 204 normal subjects which underwent a triple tracer meal protocol which provided quasi model-independent estimates of major glucose and insulin fluxes. Model results are shown in describing normal daily life (breakfast, lunch, dinner) both in normal and pathophysiological situations. The potential of the model for studying type 1 diabetes is illustrated by simulating both open- and closed-loop insulin infusion strategies.
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U2 - 10.1109/IEMBS.2006.260810
DO - 10.1109/IEMBS.2006.260810
M3 - Conference contribution
C2 - 17946394
AN - SCOPUS:34047109279
SN - 1424400325
SN - 9781424400324
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 307
EP - 310
BT - 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
T2 - 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
Y2 - 30 August 2006 through 3 September 2006
ER -