Mitral Valve Prolapse, Psychoemotional Status, and Quality of Life

Prospective Investigation in the Current Era

Tali Bayer-Topilsky, Rakesh M. Suri, Yan Topilsky, Yariv N. Marmor, Max R. Trenerry, Ryan M. Antiel, Douglas W. Mahoney, Hartzell V Schaff, Maurice E Sarano

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: The purpose of this study is to investigate whether mitral valve prolapse is associated with the patient's psychoemotional status and health-related quality of life. Methods: Mitral valve prolapse and mitral regurgitation were prospectively and comprehensively assessed in 281 patients (age 61 ± 13 years; 63% men); 216 patients with mitral valve prolapse were compared with 65 without mitral valve prolapse (of similar age and sex). Simultaneously, we assessed the patient's psychoemotional status (anxiety, depression, posttraumatic stress symptoms), health-related quality of life, and perceived severity of illness using validated questionnaires. Results: Twenty-nine percent of the patients had either no or mild mitral regurgitation (area of effective regurgitant orifice ≤0.2), and 71% had clinically significant mitral regurgitation (moderate/severe). Stratifying patients into no/mild vs moderate/severe mitral regurgitation revealed no differences in psychoemotional status or mental health-related quality of life between patients with mitral valve prolapse vs those without mitral valve prolapse within each subgroup; no/mild mitral regurgitation and moderate/severe mitral regurgitation (all P ≥ .5). In multivariate analysis, mitral valve prolapse was not independently associated with psychoemotional status or health-related quality of life (all P ≥ .4). In addition, while objective severity of the illness was not related to psychoemotional status or health-related quality of life (all P ≥ .2), the patient's perceived severity of illness predicted in and of itself all psychoemotional (all P < .03) and quality-of-life outcomes (all P < .003). Conclusion: Mitral valve prolapse is not a determinant of the patient's psychoemotional status or quality of life. Psychoemotional status and health-related quality of life are determined by the patient's perception of the severity of the mitral valve disease, rather than by the presence of mitral valve prolapse.

Original languageEnglish (US)
JournalAmerican Journal of Medicine
DOIs
StateAccepted/In press - 2016

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Mitral Valve Prolapse
Mitral Valve Insufficiency
Quality of Life
Mitral Valve
Mental Health
Multivariate Analysis
Anxiety
Depression

Keywords

  • Patient care
  • Symptoms
  • Valve disease
  • Well-being

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mitral Valve Prolapse, Psychoemotional Status, and Quality of Life : Prospective Investigation in the Current Era. / Bayer-Topilsky, Tali; Suri, Rakesh M.; Topilsky, Yan; Marmor, Yariv N.; Trenerry, Max R.; Antiel, Ryan M.; Mahoney, Douglas W.; Schaff, Hartzell V; Sarano, Maurice E.

In: American Journal of Medicine, 2016.

Research output: Contribution to journalArticle

Bayer-Topilsky, Tali ; Suri, Rakesh M. ; Topilsky, Yan ; Marmor, Yariv N. ; Trenerry, Max R. ; Antiel, Ryan M. ; Mahoney, Douglas W. ; Schaff, Hartzell V ; Sarano, Maurice E. / Mitral Valve Prolapse, Psychoemotional Status, and Quality of Life : Prospective Investigation in the Current Era. In: American Journal of Medicine. 2016.
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title = "Mitral Valve Prolapse, Psychoemotional Status, and Quality of Life: Prospective Investigation in the Current Era",
abstract = "Objective: The purpose of this study is to investigate whether mitral valve prolapse is associated with the patient's psychoemotional status and health-related quality of life. Methods: Mitral valve prolapse and mitral regurgitation were prospectively and comprehensively assessed in 281 patients (age 61 ± 13 years; 63{\%} men); 216 patients with mitral valve prolapse were compared with 65 without mitral valve prolapse (of similar age and sex). Simultaneously, we assessed the patient's psychoemotional status (anxiety, depression, posttraumatic stress symptoms), health-related quality of life, and perceived severity of illness using validated questionnaires. Results: Twenty-nine percent of the patients had either no or mild mitral regurgitation (area of effective regurgitant orifice ≤0.2), and 71{\%} had clinically significant mitral regurgitation (moderate/severe). Stratifying patients into no/mild vs moderate/severe mitral regurgitation revealed no differences in psychoemotional status or mental health-related quality of life between patients with mitral valve prolapse vs those without mitral valve prolapse within each subgroup; no/mild mitral regurgitation and moderate/severe mitral regurgitation (all P ≥ .5). In multivariate analysis, mitral valve prolapse was not independently associated with psychoemotional status or health-related quality of life (all P ≥ .4). In addition, while objective severity of the illness was not related to psychoemotional status or health-related quality of life (all P ≥ .2), the patient's perceived severity of illness predicted in and of itself all psychoemotional (all P < .03) and quality-of-life outcomes (all P < .003). Conclusion: Mitral valve prolapse is not a determinant of the patient's psychoemotional status or quality of life. Psychoemotional status and health-related quality of life are determined by the patient's perception of the severity of the mitral valve disease, rather than by the presence of mitral valve prolapse.",
keywords = "Patient care, Symptoms, Valve disease, Well-being",
author = "Tali Bayer-Topilsky and Suri, {Rakesh M.} and Yan Topilsky and Marmor, {Yariv N.} and Trenerry, {Max R.} and Antiel, {Ryan M.} and Mahoney, {Douglas W.} and Schaff, {Hartzell V} and Sarano, {Maurice E}",
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T1 - Mitral Valve Prolapse, Psychoemotional Status, and Quality of Life

T2 - Prospective Investigation in the Current Era

AU - Bayer-Topilsky, Tali

AU - Suri, Rakesh M.

AU - Topilsky, Yan

AU - Marmor, Yariv N.

AU - Trenerry, Max R.

AU - Antiel, Ryan M.

AU - Mahoney, Douglas W.

AU - Schaff, Hartzell V

AU - Sarano, Maurice E

PY - 2016

Y1 - 2016

N2 - Objective: The purpose of this study is to investigate whether mitral valve prolapse is associated with the patient's psychoemotional status and health-related quality of life. Methods: Mitral valve prolapse and mitral regurgitation were prospectively and comprehensively assessed in 281 patients (age 61 ± 13 years; 63% men); 216 patients with mitral valve prolapse were compared with 65 without mitral valve prolapse (of similar age and sex). Simultaneously, we assessed the patient's psychoemotional status (anxiety, depression, posttraumatic stress symptoms), health-related quality of life, and perceived severity of illness using validated questionnaires. Results: Twenty-nine percent of the patients had either no or mild mitral regurgitation (area of effective regurgitant orifice ≤0.2), and 71% had clinically significant mitral regurgitation (moderate/severe). Stratifying patients into no/mild vs moderate/severe mitral regurgitation revealed no differences in psychoemotional status or mental health-related quality of life between patients with mitral valve prolapse vs those without mitral valve prolapse within each subgroup; no/mild mitral regurgitation and moderate/severe mitral regurgitation (all P ≥ .5). In multivariate analysis, mitral valve prolapse was not independently associated with psychoemotional status or health-related quality of life (all P ≥ .4). In addition, while objective severity of the illness was not related to psychoemotional status or health-related quality of life (all P ≥ .2), the patient's perceived severity of illness predicted in and of itself all psychoemotional (all P < .03) and quality-of-life outcomes (all P < .003). Conclusion: Mitral valve prolapse is not a determinant of the patient's psychoemotional status or quality of life. Psychoemotional status and health-related quality of life are determined by the patient's perception of the severity of the mitral valve disease, rather than by the presence of mitral valve prolapse.

AB - Objective: The purpose of this study is to investigate whether mitral valve prolapse is associated with the patient's psychoemotional status and health-related quality of life. Methods: Mitral valve prolapse and mitral regurgitation were prospectively and comprehensively assessed in 281 patients (age 61 ± 13 years; 63% men); 216 patients with mitral valve prolapse were compared with 65 without mitral valve prolapse (of similar age and sex). Simultaneously, we assessed the patient's psychoemotional status (anxiety, depression, posttraumatic stress symptoms), health-related quality of life, and perceived severity of illness using validated questionnaires. Results: Twenty-nine percent of the patients had either no or mild mitral regurgitation (area of effective regurgitant orifice ≤0.2), and 71% had clinically significant mitral regurgitation (moderate/severe). Stratifying patients into no/mild vs moderate/severe mitral regurgitation revealed no differences in psychoemotional status or mental health-related quality of life between patients with mitral valve prolapse vs those without mitral valve prolapse within each subgroup; no/mild mitral regurgitation and moderate/severe mitral regurgitation (all P ≥ .5). In multivariate analysis, mitral valve prolapse was not independently associated with psychoemotional status or health-related quality of life (all P ≥ .4). In addition, while objective severity of the illness was not related to psychoemotional status or health-related quality of life (all P ≥ .2), the patient's perceived severity of illness predicted in and of itself all psychoemotional (all P < .03) and quality-of-life outcomes (all P < .003). Conclusion: Mitral valve prolapse is not a determinant of the patient's psychoemotional status or quality of life. Psychoemotional status and health-related quality of life are determined by the patient's perception of the severity of the mitral valve disease, rather than by the presence of mitral valve prolapse.

KW - Patient care

KW - Symptoms

KW - Valve disease

KW - Well-being

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