Mitral regurgitation: A new clinical perspective

Maurice E Sarano, Thomas A. Orszulak, Hartzell V Schaff, Martin D. Abel, A. Jamil Tajik, Robert L. Frye, Department Of Anesthesiology, Mayo Clinic Rochester

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Mitral regurgitation is a common valvular heart disease, particularly in the elderly population. The timing of surgical repair is controversial, but recent literature suggests a new clinical perspective on the management of this disease. Despite receiving medical treatment and having few initial symptoms, patients with mitral regurgitation due to flail leaflets have an excess mortality rate (6.3% per year) and high morbidity. Ten years after mitral regurgitation has been diagnosed, 90% of the patients have either died or undergone an operation. After surgical correction of mitral regurgitation, left ventricular dysfunction is a frequent complication and is the cause of excess heart failure and mortality. This complication is due to preoperative left ventricular dysfunction but is incompletely predictable with use of current methods. Conversely, considerable progress in surgery has resulted in an extremely low operative mortality rate (about 1% in patients younger than 75 years of age) and high feasibility of valve repair, even in patients with anterior leaflet prolapse. These facts have led to the new perspective that early surgical correction (before occurrence of overt symptoms or left ventricular dysfunction) should be considered when patients are diagnosed with severe mitral regurgitation.

Original languageEnglish (US)
Pages (from-to)1034-1043
Number of pages10
JournalMayo Clinic Proceedings
Volume72
Issue number11
StatePublished - 1997

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Mitral Valve Insufficiency
Left Ventricular Dysfunction
Mortality
Heart Valve Diseases
Prolapse
Disease Management
Heart Failure
Morbidity
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sarano, M. E., Orszulak, T. A., Schaff, H. V., Abel, M. D., Jamil Tajik, A., Frye, R. L., ... Rochester, M. C. (1997). Mitral regurgitation: A new clinical perspective. Mayo Clinic Proceedings, 72(11), 1034-1043.

Mitral regurgitation : A new clinical perspective. / Sarano, Maurice E; Orszulak, Thomas A.; Schaff, Hartzell V; Abel, Martin D.; Jamil Tajik, A.; Frye, Robert L.; Anesthesiology, Department Of; Rochester, Mayo Clinic.

In: Mayo Clinic Proceedings, Vol. 72, No. 11, 1997, p. 1034-1043.

Research output: Contribution to journalArticle

Sarano, ME, Orszulak, TA, Schaff, HV, Abel, MD, Jamil Tajik, A, Frye, RL, Anesthesiology, DO & Rochester, MC 1997, 'Mitral regurgitation: A new clinical perspective', Mayo Clinic Proceedings, vol. 72, no. 11, pp. 1034-1043.
Sarano ME, Orszulak TA, Schaff HV, Abel MD, Jamil Tajik A, Frye RL et al. Mitral regurgitation: A new clinical perspective. Mayo Clinic Proceedings. 1997;72(11):1034-1043.
Sarano, Maurice E ; Orszulak, Thomas A. ; Schaff, Hartzell V ; Abel, Martin D. ; Jamil Tajik, A. ; Frye, Robert L. ; Anesthesiology, Department Of ; Rochester, Mayo Clinic. / Mitral regurgitation : A new clinical perspective. In: Mayo Clinic Proceedings. 1997 ; Vol. 72, No. 11. pp. 1034-1043.
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