Mitotic gene bookmarking: An epigenetic mechanism for coordination of lineage commitment, cell identity and cell growth

Sayyed K. Zaidi, Jane B. Lian, Andre van Wijnen, Janet L. Stein, Gary S. Stein

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Epigenetic control of gene expression contributes to dynamic responsiveness of cellular processes that include cell cycle, cell growth and differentiation. Mitotic gene bookmarking, retention of sequence-specific transcription factors at target gene loci, including the RUNX regulatory proteins, provide a novel dimension to epigenetic regulation that sustains cellular identity in progeny cells following cell division. Runx transcription factor retention during mitosis coordinates physiological control of cell growth and differentiation in a broad spectrum of biological conditions, and is associated with compromised gene expression in pathologies that include cancer.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages95-102
Number of pages8
DOIs
StatePublished - 2017

Publication series

NameAdvances in Experimental Medicine and Biology
Volume962
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Epigenetic control
  • Gene expression
  • Mitotic bookmarking
  • RUNX

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Zaidi, S. K., Lian, J. B., van Wijnen, A., Stein, J. L., & Stein, G. S. (2017). Mitotic gene bookmarking: An epigenetic mechanism for coordination of lineage commitment, cell identity and cell growth. In Advances in Experimental Medicine and Biology (pp. 95-102). (Advances in Experimental Medicine and Biology; Vol. 962). Springer New York LLC. https://doi.org/10.1007/978-981-10-3233-2_7