Mitotic bookmarking of genes: A novel dimension to epigenetic control

Sayyed K. Zaidi; Daniel W. Young; Martin A. Montecino; Jane B. Lian; Andre J. Van Wijnen; Janet L. Stein; Gary S. Stein

doi:10.1038/nrg2827

Mitotic bookmarking of genes: A novel dimension to epigenetic control

Sayyed K. Zaidi, Daniel W. Young, Martin A. Montecino, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein

Orthopedic Surgery

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104 Scopus citations

Abstract

Regulatory machinery is focally organized in the interphase nucleus. The information contained in these focal nuclear microenvironments must be inherited during cell division to sustain physiologically responsive gene expression in progeny cells. Recent results suggest that focal mitotic retention of phenotypic transcription factors at promoters together with histone modifications and DNA methylation a mechanism collectively known as gene bookmarking is a novel parameter of inherited epigenetic control that sustains cellular identity after mitosis. The epigenetic signatures imposed by bookmarking poise genes for activation or suppression following mitosis. We discuss the implications of phenotypic transcription factor retention on mitotic chromosomes in biological control and disease.

Original language	English (US)
Pages (from-to)	583-589
Number of pages	7
Journal	Nature Reviews Genetics
Volume	11
Issue number	8
DOIs	https://doi.org/10.1038/nrg2827
State	Published - Aug 2010

ASJC Scopus subject areas

Molecular Biology
Genetics
Genetics(clinical)

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10.1038/nrg2827

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title = "Mitotic bookmarking of genes: A novel dimension to epigenetic control",

abstract = "Regulatory machinery is focally organized in the interphase nucleus. The information contained in these focal nuclear microenvironments must be inherited during cell division to sustain physiologically responsive gene expression in progeny cells. Recent results suggest that focal mitotic retention of phenotypic transcription factors at promoters together with histone modifications and DNA methylation a mechanism collectively known as gene bookmarking is a novel parameter of inherited epigenetic control that sustains cellular identity after mitosis. The epigenetic signatures imposed by bookmarking poise genes for activation or suppression following mitosis. We discuss the implications of phenotypic transcription factor retention on mitotic chromosomes in biological control and disease.",

author = "Zaidi, {Sayyed K.} and Young, {Daniel W.} and Montecino, {Martin A.} and Lian, {Jane B.} and {Van Wijnen}, {Andre J.} and Stein, {Janet L.} and Stein, {Gary S.}",

note = "Funding Information: The authors thank P. Jamieson for her assistance in the preparation of this article. This work was supported by National Institutes of Health grants P01 AR048818 and P01 CA082834. The contents of this paper are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health.",

year = "2010",

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doi = "10.1038/nrg2827",

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volume = "11",

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T2 - A novel dimension to epigenetic control

AU - Zaidi, Sayyed K.

AU - Young, Daniel W.

AU - Montecino, Martin A.

AU - Lian, Jane B.

AU - Van Wijnen, Andre J.

AU - Stein, Janet L.

AU - Stein, Gary S.

N1 - Funding Information: The authors thank P. Jamieson for her assistance in the preparation of this article. This work was supported by National Institutes of Health grants P01 AR048818 and P01 CA082834. The contents of this paper are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health.

PY - 2010/8

Y1 - 2010/8

N2 - Regulatory machinery is focally organized in the interphase nucleus. The information contained in these focal nuclear microenvironments must be inherited during cell division to sustain physiologically responsive gene expression in progeny cells. Recent results suggest that focal mitotic retention of phenotypic transcription factors at promoters together with histone modifications and DNA methylation a mechanism collectively known as gene bookmarking is a novel parameter of inherited epigenetic control that sustains cellular identity after mitosis. The epigenetic signatures imposed by bookmarking poise genes for activation or suppression following mitosis. We discuss the implications of phenotypic transcription factor retention on mitotic chromosomes in biological control and disease.

AB - Regulatory machinery is focally organized in the interphase nucleus. The information contained in these focal nuclear microenvironments must be inherited during cell division to sustain physiologically responsive gene expression in progeny cells. Recent results suggest that focal mitotic retention of phenotypic transcription factors at promoters together with histone modifications and DNA methylation a mechanism collectively known as gene bookmarking is a novel parameter of inherited epigenetic control that sustains cellular identity after mitosis. The epigenetic signatures imposed by bookmarking poise genes for activation or suppression following mitosis. We discuss the implications of phenotypic transcription factor retention on mitotic chromosomes in biological control and disease.

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Mitotic bookmarking of genes: A novel dimension to epigenetic control

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