Mitotane treatment in patients with metastatic testicular Leydig cell tumor associated with severe androgen excess

Vasileios Chortis, Nicholas J. Johal, Irina Bancos, Matthew Evans, Kassiani Skordilis, Peter Guest, Michael H. Cullen, Emilio Porfiri, Wiebke Arlt

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1 Scopus citations

Abstract

Mitotane (o,p′DDD) is established in the adjuvant and advanced-stage treatment of adrenocortical carcinoma and counteracts both tumor growth and tumor-related steroid production. Both the adrenal glands and the gonads are steroidogenically active organs and share a common embryogenic origin. Here, we describe the effects of mitotane in two patients with metastatic Leydig cell tumor (LCT) of the testes and associated severe androgen excess (serum testosterone 93 and 88nmol/L, respectively; male reference range 7–27nmol/L). Both men suffered from severe restlessness, insomnia and irritability, which they described as intolerable and disrupting normal life activities. Urinary steroid profiling by gas chromatography–mass spectrometry (GC–MS) confirmed excess androgen production and revealed concurrent overproduction of glucocorticoids and glucocorticoid precursors, which under physiological conditions are produced only by the adrenal glands but not by the gonads. In a palliative approach, they were commenced on mitotane, which achieved swift control of the hormone excess and the debilitating clinical symptoms, restoring normal quality of life. GC–MS demonstrated normalization of steroid production and decreased 5α-reductase activity, resulting in decreased androgen activation, and imaging demonstrated disease stabilization for 4–10 months. In conclusion, mitotane can be highly effective in controlling steroid excess in metastatic LCTs, with anti-tumor activity in some cases.

Original languageEnglish (US)
Pages (from-to)K21-K27
JournalEuropean journal of endocrinology
Volume178
Issue number3
DOIs
StatePublished - Mar 2018

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Chortis, V., Johal, N. J., Bancos, I., Evans, M., Skordilis, K., Guest, P., Cullen, M. H., Porfiri, E., & Arlt, W. (2018). Mitotane treatment in patients with metastatic testicular Leydig cell tumor associated with severe androgen excess. European journal of endocrinology, 178(3), K21-K27. https://doi.org/10.1530/EJE-17-0542