Mitofusin 2 Regulates Axonal Transport of Calpastatin to Prevent Neuromuscular Synaptic Elimination in Skeletal Muscles

Luwen Wang, Ju Gao, Jingyi Liu, Sandra L. Siedlak, Sandy Torres, Hisashi Fujioka, Mikayla L. Huntley, Yinfei Jiang, Haiyan Ji, Tingxiang Yan, Micah Harland, Pichet Termsarasab, Sophia Zeng, Zhen Jiang, Jingjing Liang, George Perry, Charles Hoppel, Cheng Zhang, Hu Li, Xinglong Wang

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Wang et al. report on the unexpected function of the mitochondrial outer membrane protein mitofusin 2 (Mfn2) in mediating the axonal transport of calpastatin, which is involved in neuromuscular function, to protect neuromuscular synapses. Mfn2 overexpression can prevent neuromuscular synapse loss in amyotrophic lateral sclerosis (ALS) and aging-related sarcopenia.

Original languageEnglish (US)
JournalCell Metabolism
DOIs
StateAccepted/In press - Jan 1 2018

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Keywords

  • amyotrophic lateral sclerosis
  • axonal transport
  • calpastatin
  • Mfn2
  • mitochondria
  • mitochondria-associated membranes
  • nerve injury
  • neuromuscular synapse
  • sarcopenia
  • skeletal muscle atrophy

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

Cite this

Wang, L., Gao, J., Liu, J., Siedlak, S. L., Torres, S., Fujioka, H., Huntley, M. L., Jiang, Y., Ji, H., Yan, T., Harland, M., Termsarasab, P., Zeng, S., Jiang, Z., Liang, J., Perry, G., Hoppel, C., Zhang, C., Li, H., & Wang, X. (Accepted/In press). Mitofusin 2 Regulates Axonal Transport of Calpastatin to Prevent Neuromuscular Synaptic Elimination in Skeletal Muscles. Cell Metabolism. https://doi.org/10.1016/j.cmet.2018.06.011