Mitochondrion-mediated apoptosis in HIV-1 infection

Andrew David Badley, Thomas Roumier, Julian J. Lum, Guido Kroemer

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Acquired immunodeficiency syndrome (AIDS), which is caused by human immunodeficiency virus (HIV-1), involves the apoptotic destruction of lymphocytes and, in the context of AIDS-associated pathologies, of neurons and myocytes. Several proteins encoded by HIV-1 trigger apoptosis by inducing permeabilization of the mitochondrial membrane. Several nucleoside analogs used clinically in the treatment of HIV-1 inhibit the replication of mitochondrial DNA (mtDNA) and/or increase the frequency of mtDNA mutations. These cause severe mitochondriopathy and might contribute to lipodystrophy, the complication associated with HIV-1 therapy. HIV-1 protease inhibitors can inhibit apoptosis at the mitochondrial level, which might help to alleviate lymphopenia. Thus, it appears that the pathogenesis of AIDS, and the pharmacological interventions and complications associated with this disease, affect the mitochondrial regulation of apoptosis, which, therefore, largely determines the outcome of HIV-1 infection.

Original languageEnglish (US)
Pages (from-to)298-305
Number of pages8
JournalTrends in Pharmacological Sciences
Volume24
Issue number6
DOIs
StatePublished - Jun 1 2003

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Mitochondria
HIV Infections
HIV-1
Apoptosis
Mitochondrial DNA
Acquired Immunodeficiency Syndrome
Lymphocytes
Pathology
Protease Inhibitors
Viruses
Nucleosides
Neurons
HIV Protease Inhibitors
Membranes
Lipodystrophy
Mitochondrial Diseases
Lymphopenia
Mitochondrial Membranes
Muscle Cells
Proteins

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Mitochondrion-mediated apoptosis in HIV-1 infection. / Badley, Andrew David; Roumier, Thomas; Lum, Julian J.; Kroemer, Guido.

In: Trends in Pharmacological Sciences, Vol. 24, No. 6, 01.06.2003, p. 298-305.

Research output: Contribution to journalArticle

Badley, Andrew David ; Roumier, Thomas ; Lum, Julian J. ; Kroemer, Guido. / Mitochondrion-mediated apoptosis in HIV-1 infection. In: Trends in Pharmacological Sciences. 2003 ; Vol. 24, No. 6. pp. 298-305.
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