Mitochondrial translation initiation factor 3 polymorphism and Parkinson's disease

Bahareh Behrouz, Carles Vilariño-Güell, Michael G. Heckman, Alexandra I. Soto-Ortolaza, Jan O. Aasly, Sigrid Sando, Timothy Lynch, David Craig, Ryan J. Uitti, Zbigniew K Wszolek, Owen A Ross, Matthew J. Farrer

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Mitochondrial dysfunction has been proposed to play a role in the pathogenesis of Parkinson's disease (PD). Supportive of this hypothesis, several genetic variants that regulate mitochondrial function and homeostasis have been described to alter PD susceptibility. A recent report demonstrated association of a single nucleotide polymorphism in the mitochondrial translation initiation factor 3 (MTIF3) gene with PD risk. The protein encoded by this nuclear gene is essential for initiation complex formation on the mitochondrial 55S ribosome and regulates translation of proteins within the mitochondria. Changes in the function or expression of the MTIF3 protein may result in altered mitochondrial function, ATP production or formation of reactive oxygen species thereby affecting susceptibility to PD. We examined the association of rs7669 with sporadic PD in three Caucasian case control series (n= 2434). A significant association was observed in the largest series (Norwegian; n= 1650) when comparing CC vs. CT/TT genotypes, with the Irish and US series having a similar but non-significant trend. The combined series also revealed an association with risk of PD (P= 0.01), supporting the possible involvement of this gene in PD etiology.

Original languageEnglish (US)
Pages (from-to)228-230
Number of pages3
JournalNeuroscience Letters
Volume486
Issue number3
DOIs
StatePublished - Dec 17 2010

Fingerprint

Prokaryotic Initiation Factor-3
Parkinson Disease
Essential Genes
Disease Susceptibility
Protein Biosynthesis
Nuclear Proteins
Genes
Single Nucleotide Polymorphism
Reactive Oxygen Species
Mitochondria
Homeostasis
Adenosine Triphosphate
Genotype

Keywords

  • Association studies
  • Genetics
  • MTIF3
  • Parkinson's disease

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Behrouz, B., Vilariño-Güell, C., Heckman, M. G., Soto-Ortolaza, A. I., Aasly, J. O., Sando, S., ... Farrer, M. J. (2010). Mitochondrial translation initiation factor 3 polymorphism and Parkinson's disease. Neuroscience Letters, 486(3), 228-230. https://doi.org/10.1016/j.neulet.2010.09.059

Mitochondrial translation initiation factor 3 polymorphism and Parkinson's disease. / Behrouz, Bahareh; Vilariño-Güell, Carles; Heckman, Michael G.; Soto-Ortolaza, Alexandra I.; Aasly, Jan O.; Sando, Sigrid; Lynch, Timothy; Craig, David; Uitti, Ryan J.; Wszolek, Zbigniew K; Ross, Owen A; Farrer, Matthew J.

In: Neuroscience Letters, Vol. 486, No. 3, 17.12.2010, p. 228-230.

Research output: Contribution to journalArticle

Behrouz, B, Vilariño-Güell, C, Heckman, MG, Soto-Ortolaza, AI, Aasly, JO, Sando, S, Lynch, T, Craig, D, Uitti, RJ, Wszolek, ZK, Ross, OA & Farrer, MJ 2010, 'Mitochondrial translation initiation factor 3 polymorphism and Parkinson's disease', Neuroscience Letters, vol. 486, no. 3, pp. 228-230. https://doi.org/10.1016/j.neulet.2010.09.059
Behrouz B, Vilariño-Güell C, Heckman MG, Soto-Ortolaza AI, Aasly JO, Sando S et al. Mitochondrial translation initiation factor 3 polymorphism and Parkinson's disease. Neuroscience Letters. 2010 Dec 17;486(3):228-230. https://doi.org/10.1016/j.neulet.2010.09.059
Behrouz, Bahareh ; Vilariño-Güell, Carles ; Heckman, Michael G. ; Soto-Ortolaza, Alexandra I. ; Aasly, Jan O. ; Sando, Sigrid ; Lynch, Timothy ; Craig, David ; Uitti, Ryan J. ; Wszolek, Zbigniew K ; Ross, Owen A ; Farrer, Matthew J. / Mitochondrial translation initiation factor 3 polymorphism and Parkinson's disease. In: Neuroscience Letters. 2010 ; Vol. 486, No. 3. pp. 228-230.
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