Mitochondrial ROS - radical detoxification, mediated by protein kinase D

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

The mitochondrial electron transport chain is the major source for the production of oxygen radicals. Mitochondria-generated reactive oxygen species (mROS) have been implicated in decreasing the life span and contributing to age-related diseases (known as the free radical theory of aging). Recently, the serine/threonine kinase protein kinase D1 (PKD1) was identified as a mitochondrial sensor for oxidative stress. mROS-activated PKD regulates a radical-sensing signaling pathway, which relays mROS production to the induction of nuclear genes that mediate cellular detoxification and survival. This PKD regulated signaling pathway is the first known mitochondria located and mitochondrially regulated antioxidant system that protects these organelles and cells from oxidative stress-mediated damage or cell death. The identification of this and further intracellular protective signaling pathways provides an opportunity to manipulate the effects of mROS, and might provide the key to targeting aging effects and age-related diseases that have been linked to mitochondrial dysfunctions.

Original languageEnglish (US)
Pages (from-to)13-18
Number of pages6
JournalTrends in Cell Biology
Volume17
Issue number1
DOIs
StatePublished - Jan 2007

Fingerprint

Reactive Oxygen Species
Mitochondria
Oxidative Stress
Protein-Serine-Threonine Kinases
Electron Transport
Organelles
Protein Kinases
Free Radicals
Cell Death
Antioxidants
protein kinase D
Genes

ASJC Scopus subject areas

  • Cell Biology

Cite this

Mitochondrial ROS - radical detoxification, mediated by protein kinase D. / Storz, Peter.

In: Trends in Cell Biology, Vol. 17, No. 1, 01.2007, p. 13-18.

Research output: Contribution to journalArticle

@article{d77643211563473893f9eebdcbb86535,
title = "Mitochondrial ROS - radical detoxification, mediated by protein kinase D",
abstract = "The mitochondrial electron transport chain is the major source for the production of oxygen radicals. Mitochondria-generated reactive oxygen species (mROS) have been implicated in decreasing the life span and contributing to age-related diseases (known as the free radical theory of aging). Recently, the serine/threonine kinase protein kinase D1 (PKD1) was identified as a mitochondrial sensor for oxidative stress. mROS-activated PKD regulates a radical-sensing signaling pathway, which relays mROS production to the induction of nuclear genes that mediate cellular detoxification and survival. This PKD regulated signaling pathway is the first known mitochondria located and mitochondrially regulated antioxidant system that protects these organelles and cells from oxidative stress-mediated damage or cell death. The identification of this and further intracellular protective signaling pathways provides an opportunity to manipulate the effects of mROS, and might provide the key to targeting aging effects and age-related diseases that have been linked to mitochondrial dysfunctions.",
author = "Peter Storz",
year = "2007",
month = "1",
doi = "10.1016/j.tcb.2006.11.003",
language = "English (US)",
volume = "17",
pages = "13--18",
journal = "Trends in Cell Biology",
issn = "0962-8924",
publisher = "Elsevier Limited",
number = "1",

}

TY - JOUR

T1 - Mitochondrial ROS - radical detoxification, mediated by protein kinase D

AU - Storz, Peter

PY - 2007/1

Y1 - 2007/1

N2 - The mitochondrial electron transport chain is the major source for the production of oxygen radicals. Mitochondria-generated reactive oxygen species (mROS) have been implicated in decreasing the life span and contributing to age-related diseases (known as the free radical theory of aging). Recently, the serine/threonine kinase protein kinase D1 (PKD1) was identified as a mitochondrial sensor for oxidative stress. mROS-activated PKD regulates a radical-sensing signaling pathway, which relays mROS production to the induction of nuclear genes that mediate cellular detoxification and survival. This PKD regulated signaling pathway is the first known mitochondria located and mitochondrially regulated antioxidant system that protects these organelles and cells from oxidative stress-mediated damage or cell death. The identification of this and further intracellular protective signaling pathways provides an opportunity to manipulate the effects of mROS, and might provide the key to targeting aging effects and age-related diseases that have been linked to mitochondrial dysfunctions.

AB - The mitochondrial electron transport chain is the major source for the production of oxygen radicals. Mitochondria-generated reactive oxygen species (mROS) have been implicated in decreasing the life span and contributing to age-related diseases (known as the free radical theory of aging). Recently, the serine/threonine kinase protein kinase D1 (PKD1) was identified as a mitochondrial sensor for oxidative stress. mROS-activated PKD regulates a radical-sensing signaling pathway, which relays mROS production to the induction of nuclear genes that mediate cellular detoxification and survival. This PKD regulated signaling pathway is the first known mitochondria located and mitochondrially regulated antioxidant system that protects these organelles and cells from oxidative stress-mediated damage or cell death. The identification of this and further intracellular protective signaling pathways provides an opportunity to manipulate the effects of mROS, and might provide the key to targeting aging effects and age-related diseases that have been linked to mitochondrial dysfunctions.

UR - http://www.scopus.com/inward/record.url?scp=33845953689&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845953689&partnerID=8YFLogxK

U2 - 10.1016/j.tcb.2006.11.003

DO - 10.1016/j.tcb.2006.11.003

M3 - Article

VL - 17

SP - 13

EP - 18

JO - Trends in Cell Biology

JF - Trends in Cell Biology

SN - 0962-8924

IS - 1

ER -