Mitochondrial myopathy presenting as Rhabdomyolysis

David C. Patchett, Michael L. Grover

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A 37-year-old white woman presented with acute bilateral hamstring pain after hiking. She had a creatine kinase level of 11,144 U/L. Rhabdomyolysis was diagnosed and the patient was admitted for intravenous fluid hydration. The patient continued to have exercise-induced myalgias and elevations in her creatine kinase level. Rheumatologic causes were ruled out and results from electromyogram testing were nondiagnostic. A muscle biopsy revealed a mitochondrial myopathy. The 22 mitochondrial DNA and transfer RNA genes were sequenced. An A-to-G transition was found at nucleotide position 4281 in the transfer RNA isoleucine gene. The patient was placed on a regimen of riboflavin, vitamin C, and coenzyme Q10, which provided mild relief. The patient returned to the emergency department 2 more times after vigorous exercise, with creatine kinase levels as high as 2800 U/L. At last follow-up, the patient was using a fentanyl citrate transdermal patch, which enabled her to perform moderate exercise without pain.

Original languageEnglish (US)
Pages (from-to)404-405
Number of pages2
JournalJournal of the American Osteopathic Association
Volume111
Issue number6
StatePublished - Jun 2011

Fingerprint

Mitochondrial Myopathies
Rhabdomyolysis
Creatine Kinase
coenzyme Q10
Exercise
Transfer RNA
Transdermal Patch
Pain
Riboflavin
Isoleucine
Myalgia
Electromyography
Fentanyl
Mitochondrial DNA
Genes
Ascorbic Acid
Hospital Emergency Service
Nucleotides
Biopsy
Muscles

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Medicine(all)

Cite this

Mitochondrial myopathy presenting as Rhabdomyolysis. / Patchett, David C.; Grover, Michael L.

In: Journal of the American Osteopathic Association, Vol. 111, No. 6, 06.2011, p. 404-405.

Research output: Contribution to journalArticle

Patchett, DC & Grover, ML 2011, 'Mitochondrial myopathy presenting as Rhabdomyolysis', Journal of the American Osteopathic Association, vol. 111, no. 6, pp. 404-405.
Patchett, David C. ; Grover, Michael L. / Mitochondrial myopathy presenting as Rhabdomyolysis. In: Journal of the American Osteopathic Association. 2011 ; Vol. 111, No. 6. pp. 404-405.
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