Mitochondrial genetic polymorphisms do not predict survival in patients with pancreatic cancer

Thorvardur R. Halfdanarson, Liang Wang, William R. Bamlet, Mariza De Andrade, Robert R Mc Williams, Julie M Cunningham, Gloria M Petersen

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Pancreatic cancer is a highly lethal malignancy, and the majority of patients succumb to the disease within 2 years. We evaluated the role of variants of mitochondrial DNA and mitochondrial haplogroups in predicting prognosis of patients with pancreatic cancer. A total of 24 mitochondrial single nucleotide polymorphisms were genotyped in 990 patients with pancreatic cancer. After adjusting for covariates and multiple comparisons, no association between any of the mitochondrial single nucleotide polymorphisms or haplogroups and survival was observed.

Original languageEnglish (US)
Pages (from-to)2512-2513
Number of pages2
JournalCancer Epidemiology Biomarkers and Prevention
Volume17
Issue number9
DOIs
StatePublished - Sep 2008

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Genetic Polymorphisms
Pancreatic Neoplasms
Single Nucleotide Polymorphism
Survival
Mitochondrial DNA
Neoplasms

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Mitochondrial genetic polymorphisms do not predict survival in patients with pancreatic cancer. / Halfdanarson, Thorvardur R.; Wang, Liang; Bamlet, William R.; De Andrade, Mariza; Mc Williams, Robert R; Cunningham, Julie M; Petersen, Gloria M.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 17, No. 9, 09.2008, p. 2512-2513.

Research output: Contribution to journalArticle

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