TY - JOUR
T1 - Mitochondrial genetic polymorphisms do not predict survival in patients with pancreatic cancer
AU - Halfdanarson, Thorvardur R.
AU - Wang, Liang
AU - Bamlet, William R.
AU - De Andrade, Mariza
AU - McWilliams, Robert R.
AU - Cunningham, Julie M.
AU - Petersen, Gloria M.
PY - 2008/9
Y1 - 2008/9
N2 - Pancreatic cancer is a highly lethal malignancy, and the majority of patients succumb to the disease within 2 years. We evaluated the role of variants of mitochondrial DNA and mitochondrial haplogroups in predicting prognosis of patients with pancreatic cancer. A total of 24 mitochondrial single nucleotide polymorphisms were genotyped in 990 patients with pancreatic cancer. After adjusting for covariates and multiple comparisons, no association between any of the mitochondrial single nucleotide polymorphisms or haplogroups and survival was observed.
AB - Pancreatic cancer is a highly lethal malignancy, and the majority of patients succumb to the disease within 2 years. We evaluated the role of variants of mitochondrial DNA and mitochondrial haplogroups in predicting prognosis of patients with pancreatic cancer. A total of 24 mitochondrial single nucleotide polymorphisms were genotyped in 990 patients with pancreatic cancer. After adjusting for covariates and multiple comparisons, no association between any of the mitochondrial single nucleotide polymorphisms or haplogroups and survival was observed.
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U2 - 10.1158/1055-9965.EPI-08-0460
DO - 10.1158/1055-9965.EPI-08-0460
M3 - Article
C2 - 18768524
AN - SCOPUS:53349156580
SN - 1055-9965
VL - 17
SP - 2512
EP - 2513
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 9
ER -