TY - JOUR
T1 - Mitochondrial dysfunction and cell senescence
T2 - Cause or consequence?
AU - Passos, João F.
AU - Von Zglinicki, Thomas
AU - Saretzki, Gabriele
PY - 2006/3/1
Y1 - 2006/3/1
N2 - The mitochondrial theory of aging remains to date one of the most popular theories of aging. One major model of aging is replicative senescence, where the irreversible loss of division potential of somatic cells occurs after a more or less constant number of cell divisions. Few data are available concerning the role of mitochondria in this model. Here, we review evidence supporting the involvement of mitochondria in replicative senescence and a possible link to telomere biology. Moreover, we suggest that this process might be more complex than originally formulated, because variations in nuclear gene expression involved in mitochondrion nucleus cross-talk are observed in both senescence and immortalization.
AB - The mitochondrial theory of aging remains to date one of the most popular theories of aging. One major model of aging is replicative senescence, where the irreversible loss of division potential of somatic cells occurs after a more or less constant number of cell divisions. Few data are available concerning the role of mitochondria in this model. Here, we review evidence supporting the involvement of mitochondria in replicative senescence and a possible link to telomere biology. Moreover, we suggest that this process might be more complex than originally formulated, because variations in nuclear gene expression involved in mitochondrion nucleus cross-talk are observed in both senescence and immortalization.
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U2 - 10.1089/rej.2006.9.64
DO - 10.1089/rej.2006.9.64
M3 - Article
C2 - 16608398
AN - SCOPUS:33646056352
SN - 1549-1684
VL - 9
SP - 64
EP - 68
JO - Rejuvenation Research
JF - Rejuvenation Research
IS - 1
ER -