Mitochondrial dysfunction and cell senescence: Cause or consequence?

João F. Passos, Thomas Von Zglinicki, Gabriele Saretzki

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


The mitochondrial theory of aging remains to date one of the most popular theories of aging. One major model of aging is replicative senescence, where the irreversible loss of division potential of somatic cells occurs after a more or less constant number of cell divisions. Few data are available concerning the role of mitochondria in this model. Here, we review evidence supporting the involvement of mitochondria in replicative senescence and a possible link to telomere biology. Moreover, we suggest that this process might be more complex than originally formulated, because variations in nuclear gene expression involved in mitochondrion nucleus cross-talk are observed in both senescence and immortalization.

Original languageEnglish (US)
Pages (from-to)64-68
Number of pages5
JournalRejuvenation Research
Issue number1
StatePublished - Mar 1 2006

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology


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