Mitochondrial dynamics and transport in Alzheimer's disease

Padraig J. Flannery, Eugenia Trushina

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Mitochondrial dysfunction is now recognized as a contributing factor to the early pathology of multiple human conditions including neurodegenerative diseases. Mitochondria are signaling organelles with a multitude of functions ranging from energy production to a regulation of cellular metabolism, energy homeostasis, stress response, and cell fate. The success of these complex processes critically depends on the fidelity of mitochondrial dynamics that include the ability of mitochondria to change shape and location in the cell, which is essential for the maintenance of proper function and quality control, particularly in polarized cells such as neurons. This review highlights several aspects of alterations in mitochondrial dynamics in Alzheimer's disease, which may contribute to the etiology of this debilitating condition. We also discuss therapeutic strategies to improve mitochondrial dynamics and function that may provide an alternative approach to failed amyloid-directed interventions.

Original languageEnglish (US)
Pages (from-to)109-120
Number of pages12
JournalMolecular and Cellular Neuroscience
Volume98
DOIs
StatePublished - Jul 2019

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Keywords

  • Alzheimer's disease
  • Axonal trafficking
  • Fission
  • Fusion
  • Mitochondria
  • Mitochondria-targeted therapeutics
  • Mitophagy

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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