Mitochondrial Changes in Cidofovir Therapy for BK Virus Nephropathy

G. Talmon, L. D. Cornell, D. J. Lager

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Polyoma (BK) virus nephropathy (BKVN) is often treated with the nucleotide analog cidofovir. An adverse effect of this drug class is proximal tubular toxicity, and ultrastructural abnormalities in proximal tubular mitochondria have been observed in patients treated with similar drugs for other viral infections. We report similar changes in biopsies from BKVN treated with cidofovir. Renal allograft biopsies showing BKVN, on which electron microscopy was performed, were categorized into 3 groups: initial diagnosis (BD), postcidofovir treatment (CT), and posttreatment with immunosuppression reduction (IR). Nineteen cases from each group were randomly selected. Mitochondrial changes were present in 6 biopsies from patients receiving CT therapy (31.5%), ranging from diffuse mitochondrial swelling to profound morphologic changes. No similar abnormalities were seen in other groups. In those with atypical mitochondria, the mean number of cidofovir doses was 2.67, with an average interval between last dose and biopsy of 2.17 weeks. CT patients without mitochondrial changes had a mean of 4.6 doses and an average interval between last dose and biopsy of 27.2 weeks. Some renal transplant patients treated with cidofovir display alterations in proximal tubular mitochondria akin to those seen with similar drugs. The findings support the mitochondrial toxicity of nucleotide analogs.

Original languageEnglish (US)
Pages (from-to)1713-1715
Number of pages3
JournalTransplantation Proceedings
Volume42
Issue number5
DOIs
StatePublished - Jun 2010
Externally publishedYes

Fingerprint

BK Virus
Biopsy
Mitochondria
Nucleotides
Pharmaceutical Preparations
Mitochondrial Swelling
Kidney
Therapeutics
Polyomavirus
Virus Diseases
Immunosuppression
Allografts
Electron Microscopy
cidofovir
Transplants

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Mitochondrial Changes in Cidofovir Therapy for BK Virus Nephropathy. / Talmon, G.; Cornell, L. D.; Lager, D. J.

In: Transplantation Proceedings, Vol. 42, No. 5, 06.2010, p. 1713-1715.

Research output: Contribution to journalArticle

Talmon, G. ; Cornell, L. D. ; Lager, D. J. / Mitochondrial Changes in Cidofovir Therapy for BK Virus Nephropathy. In: Transplantation Proceedings. 2010 ; Vol. 42, No. 5. pp. 1713-1715.
@article{db879da4715145c8a8a7c287486f8a38,
title = "Mitochondrial Changes in Cidofovir Therapy for BK Virus Nephropathy",
abstract = "Polyoma (BK) virus nephropathy (BKVN) is often treated with the nucleotide analog cidofovir. An adverse effect of this drug class is proximal tubular toxicity, and ultrastructural abnormalities in proximal tubular mitochondria have been observed in patients treated with similar drugs for other viral infections. We report similar changes in biopsies from BKVN treated with cidofovir. Renal allograft biopsies showing BKVN, on which electron microscopy was performed, were categorized into 3 groups: initial diagnosis (BD), postcidofovir treatment (CT), and posttreatment with immunosuppression reduction (IR). Nineteen cases from each group were randomly selected. Mitochondrial changes were present in 6 biopsies from patients receiving CT therapy (31.5{\%}), ranging from diffuse mitochondrial swelling to profound morphologic changes. No similar abnormalities were seen in other groups. In those with atypical mitochondria, the mean number of cidofovir doses was 2.67, with an average interval between last dose and biopsy of 2.17 weeks. CT patients without mitochondrial changes had a mean of 4.6 doses and an average interval between last dose and biopsy of 27.2 weeks. Some renal transplant patients treated with cidofovir display alterations in proximal tubular mitochondria akin to those seen with similar drugs. The findings support the mitochondrial toxicity of nucleotide analogs.",
author = "G. Talmon and Cornell, {L. D.} and Lager, {D. J.}",
year = "2010",
month = "6",
doi = "10.1016/j.transproceed.2009.11.039",
language = "English (US)",
volume = "42",
pages = "1713--1715",
journal = "Transplantation Proceedings",
issn = "0041-1345",
publisher = "Elsevier USA",
number = "5",

}

TY - JOUR

T1 - Mitochondrial Changes in Cidofovir Therapy for BK Virus Nephropathy

AU - Talmon, G.

AU - Cornell, L. D.

AU - Lager, D. J.

PY - 2010/6

Y1 - 2010/6

N2 - Polyoma (BK) virus nephropathy (BKVN) is often treated with the nucleotide analog cidofovir. An adverse effect of this drug class is proximal tubular toxicity, and ultrastructural abnormalities in proximal tubular mitochondria have been observed in patients treated with similar drugs for other viral infections. We report similar changes in biopsies from BKVN treated with cidofovir. Renal allograft biopsies showing BKVN, on which electron microscopy was performed, were categorized into 3 groups: initial diagnosis (BD), postcidofovir treatment (CT), and posttreatment with immunosuppression reduction (IR). Nineteen cases from each group were randomly selected. Mitochondrial changes were present in 6 biopsies from patients receiving CT therapy (31.5%), ranging from diffuse mitochondrial swelling to profound morphologic changes. No similar abnormalities were seen in other groups. In those with atypical mitochondria, the mean number of cidofovir doses was 2.67, with an average interval between last dose and biopsy of 2.17 weeks. CT patients without mitochondrial changes had a mean of 4.6 doses and an average interval between last dose and biopsy of 27.2 weeks. Some renal transplant patients treated with cidofovir display alterations in proximal tubular mitochondria akin to those seen with similar drugs. The findings support the mitochondrial toxicity of nucleotide analogs.

AB - Polyoma (BK) virus nephropathy (BKVN) is often treated with the nucleotide analog cidofovir. An adverse effect of this drug class is proximal tubular toxicity, and ultrastructural abnormalities in proximal tubular mitochondria have been observed in patients treated with similar drugs for other viral infections. We report similar changes in biopsies from BKVN treated with cidofovir. Renal allograft biopsies showing BKVN, on which electron microscopy was performed, were categorized into 3 groups: initial diagnosis (BD), postcidofovir treatment (CT), and posttreatment with immunosuppression reduction (IR). Nineteen cases from each group were randomly selected. Mitochondrial changes were present in 6 biopsies from patients receiving CT therapy (31.5%), ranging from diffuse mitochondrial swelling to profound morphologic changes. No similar abnormalities were seen in other groups. In those with atypical mitochondria, the mean number of cidofovir doses was 2.67, with an average interval between last dose and biopsy of 2.17 weeks. CT patients without mitochondrial changes had a mean of 4.6 doses and an average interval between last dose and biopsy of 27.2 weeks. Some renal transplant patients treated with cidofovir display alterations in proximal tubular mitochondria akin to those seen with similar drugs. The findings support the mitochondrial toxicity of nucleotide analogs.

UR - http://www.scopus.com/inward/record.url?scp=77953661284&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953661284&partnerID=8YFLogxK

U2 - 10.1016/j.transproceed.2009.11.039

DO - 10.1016/j.transproceed.2009.11.039

M3 - Article

C2 - 20620507

AN - SCOPUS:77953661284

VL - 42

SP - 1713

EP - 1715

JO - Transplantation Proceedings

JF - Transplantation Proceedings

SN - 0041-1345

IS - 5

ER -