Mitochondrial and skeletal muscle health with advancing age

Adam R. Konopka, K. Sreekumaran Nair

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

With increasing age there is a temporal relationship between the decline of mitochondrial and skeletal muscle volume, quality and function (i.e., health). Reduced mitochondrial mRNA expression, protein abundance, and protein synthesis rates appear to promote the decline of mitochondrial protein quality and function. Decreased mitochondrial function is suspected to impede energy demanding processes such as skeletal muscle protein turnover, which is critical for maintaining protein quality and thus skeletal muscle health with advancing age. The focus of this review was to discuss promising human physiological systems underpinning the decline of mitochondrial and skeletal muscle health with advancing age while highlighting therapeutic strategies such as aerobic exercise and caloric restriction for combating age-related functional impairments.

Original languageEnglish (US)
Pages (from-to)19-29
Number of pages11
JournalMolecular and Cellular Endocrinology
Volume379
Issue number1-2
DOIs
StatePublished - Oct 15 2013

Keywords

  • Aging
  • Mitochondria
  • Protein metabolism
  • Sarcopenia

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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