TY - JOUR
T1 - Mitochondria in pluripotent stem cells
T2 - Stemness regulators and disease targets
AU - Folmes, Clifford D.L.
AU - Ma, Hong
AU - Mitalipov, Shoukhrat
AU - Terzic, Andre
N1 - Publisher Copyright:
© 2016 Elsevier Ltd.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Beyond their canonical role in efficient ATP production through oxidative metabolism, mitochondria are increasingly recognized as critical in defining stem cell function and fate. Implicating a fundamental interplay within the epigenetics of eukaryotic cell systems, the integrity of mitochondria is found vital across the developmental/differentiation spectrum from securing pluripotency maintenance to informing organotypic decisions. This overview will discuss recent progress on examining the plasticity of mitochondria in enabling the execution of programming and reprogramming regimens, as well as the application of nuclear reprogramming and somatic cell nuclear transfer as rescue techniques to generate genetically and functionally corrected pluripotent stem cells from patients with mitochondrial DNA-based disease.
AB - Beyond their canonical role in efficient ATP production through oxidative metabolism, mitochondria are increasingly recognized as critical in defining stem cell function and fate. Implicating a fundamental interplay within the epigenetics of eukaryotic cell systems, the integrity of mitochondria is found vital across the developmental/differentiation spectrum from securing pluripotency maintenance to informing organotypic decisions. This overview will discuss recent progress on examining the plasticity of mitochondria in enabling the execution of programming and reprogramming regimens, as well as the application of nuclear reprogramming and somatic cell nuclear transfer as rescue techniques to generate genetically and functionally corrected pluripotent stem cells from patients with mitochondrial DNA-based disease.
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U2 - 10.1016/j.gde.2016.02.001
DO - 10.1016/j.gde.2016.02.001
M3 - Review article
C2 - 26953561
AN - SCOPUS:84959289575
SN - 0959-437X
VL - 38
SP - 1
EP - 7
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
ER -