Mitochondria in lung diseases

Bharathi Aravamudan, Michael A. Thompson, Christina M. Pabelick, Y. S. Prakash

Research output: Contribution to journalReview article

48 Scopus citations

Abstract

Mitochondria are autonomous cellular organelles that oversee a variety of functions such as metabolism, energy production, calcium buffering and cell fate determination. Regulation of their morphology and diverse activities beyond energy production are being recognized as playing major roles in cellular health and dysfunction. This review is aimed at summarizing what is known regarding mitochondrial contributions to pathogenesis of lung diseases. Emphasis is given to understanding the importance of structural and functional aspects of mitochondria in both normal cellular function (based on knowledge from other cell types) and in development and modulation of lung diseases such as asthma, chronic obstructive pulmonary disease, cystic fibrosis and cancer. Emerging techniques that allow examination of mitochondria, and potential strategies to target mitochondria in the treatment of lung diseases are also discussed.

Original languageEnglish (US)
Pages (from-to)631-646
Number of pages16
JournalExpert Review of Respiratory Medicine
Volume7
Issue number6
DOIs
StatePublished - 2013

Keywords

  • Airway
  • Apoptosis
  • Autophagy
  • Fission
  • Fusion
  • Mitochondria
  • Oxidative stress
  • Proliferation
  • Reactive oxygen species

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine
  • Public Health, Environmental and Occupational Health

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